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The 21st century epidemic: infections as inductors of neuro-degeneration associated with Alzheimer’s Disease

Overview of attention for article published in Immunity & Ageing, December 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

blogs
1 blog
twitter
2 X users

Citations

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24 Dimensions

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59 Mendeley
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Title
The 21st century epidemic: infections as inductors of neuro-degeneration associated with Alzheimer’s Disease
Published in
Immunity & Ageing, December 2014
DOI 10.1186/s12979-014-0022-8
Pubmed ID
Authors

Federico Licastro, Ilaria Carbone, Elena Raschi, Elisa Porcellini

Abstract

Alzheimer's disease (AD) is a complex disease resulting in neurodegeneration and cognitive impairment. Investigations on environmental factors implicated in AD are scarce and the etiology of the disease remains up to now obscure. The disease's pathogenesis may be multi-factorial and different etiological factors may converge during aging and induce an activation of brain microglia and macrophages. This microglia priming will result in chronic neuro-inflammation under chronic antigen activation. Infective agents may prime and drive iper-activation of microglia and be partially responsible of the induction of brain inflammation and decline of cognitive performances. Age-associated immune dis-functions induced by chronic sub-clinical infections appear to substantially contribute to the appearance of neuro-inflammation in the elderly. Individual predisposition to less efficient immune responses is another relevant factor contributing to impaired regulation of inflammatory responses and accelerated cognitive decline. Life-long virus infection may play a pivotal role in activating peripheral and central inflammatory responses and in turn contributing to increased cognitive impairment in preclinical and clinical AD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 2%
Netherlands 1 2%
Greece 1 2%
Switzerland 1 2%
Unknown 55 93%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 19%
Student > Master 8 14%
Student > Ph. D. Student 6 10%
Student > Doctoral Student 3 5%
Researcher 3 5%
Other 10 17%
Unknown 18 31%
Readers by discipline Count As %
Medicine and Dentistry 11 19%
Agricultural and Biological Sciences 6 10%
Neuroscience 6 10%
Biochemistry, Genetics and Molecular Biology 5 8%
Nursing and Health Professions 2 3%
Other 6 10%
Unknown 23 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2017.
All research outputs
#2,583,935
of 22,774,233 outputs
Outputs from Immunity & Ageing
#71
of 372 outputs
Outputs of similar age
#38,064
of 359,774 outputs
Outputs of similar age from Immunity & Ageing
#3
of 11 outputs
Altmetric has tracked 22,774,233 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 372 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.8. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,774 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.