Title |
Oxidative stress and cellular pathologies in Parkinson’s disease
|
---|---|
Published in |
Molecular Brain, November 2017
|
DOI | 10.1186/s13041-017-0340-9 |
Pubmed ID | |
Authors |
Lesly Puspita, Sun Young Chung, Jae-won Shim |
Abstract |
Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine neurons in the substantia nigra. The reason for the death of these neurons is unclear; however, studies have demonstrated the potential involvement of mitochondria, endoplasmic reticulum, α-synuclein or dopamine levels in contributing to cellular oxidative stress as well as PD symptoms. Even though those papers had separately described the individual roles of each element leading to neurodegeneration, recent publications suggest that neurodegeneration is the product of various cellular interactions. This review discusses the role of oxidative stress in mediating separate pathological events that together, ultimately result in cell death in PD. Understanding the multi-faceted relationships between these events, with oxidative stress as a common denominator underlying these processes, is needed for developing better therapeutic strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 472 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 66 | 14% |
Student > Master | 64 | 14% |
Student > Ph. D. Student | 61 | 13% |
Researcher | 40 | 8% |
Student > Doctoral Student | 35 | 7% |
Other | 51 | 11% |
Unknown | 155 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 79 | 17% |
Neuroscience | 64 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 49 | 10% |
Medicine and Dentistry | 41 | 9% |
Agricultural and Biological Sciences | 27 | 6% |
Other | 40 | 8% |
Unknown | 172 | 36% |