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Natural attack rate of influenza in unvaccinated children and adults: a meta-regression analysis

Overview of attention for article published in BMC Infectious Diseases, December 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

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2 news outlets
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Title
Natural attack rate of influenza in unvaccinated children and adults: a meta-regression analysis
Published in
BMC Infectious Diseases, December 2014
DOI 10.1186/s12879-014-0670-5
Pubmed ID
Authors

Kavisha Jayasundara, Charlene Soobiah, Edward Thommes, Andrea C Tricco, Ayman Chit

Abstract

BackgroundThe natural (i.e. unvaccinated population) attack rate of an infectious disease is an important parameter required for understanding disease transmission. As such, it is an input parameter in infectious disease mathematical models. Influenza is an infectious disease that poses a major health concern worldwide and the natural attack rate of this disease is crucial in determining the effectiveness and cost-effectiveness of public health interventions and informing surveillance program design. We estimated age-stratified, strain-specific natural attack rates of laboratory-confirmed influenza in unvaccinated individuals.MethodsUtilizing an existing systematic review, we calculated the attack rates in the trial placebo arms using a random effects model and a meta-regression analysis (GSK study identifier: 117102).ResultsThis post-hoc analysis included 34 RCTs (Randomized Control Trials) contributing to 47 influenza seasons from 1970 to 2009. Meta-regression analyses showed that age and type of influenza were important covariates. The attack rates (95% CI (Confidence Interval)) in adults for all influenza, type A and type B were 3.50% (2.30%, 4.60%), 2.32% (1.47%, 3.17%) and 0.59% (0.28%, 0.91%) respectively. For children, they were 15.20% (11.40%, 18.90%), 12.27% (8.56%, 15.97%) and 5.50% (3.49%, 7.51%) respectively.ConclusionsThis analysis demonstrated that unvaccinated children have considerably higher exposure risk than adults and influenza A can cause more disease than influenza B. Moreover, a higher ratio of influenza B:A in children than adults was observed. This study provides a new, stratified and up to-date natural attack rates that can be used in influenza infectious disease models and are consistent with previous published work in the field.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 94 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 16%
Researcher 11 12%
Student > Master 10 11%
Student > Postgraduate 6 6%
Student > Bachelor 5 5%
Other 17 18%
Unknown 30 32%
Readers by discipline Count As %
Medicine and Dentistry 22 23%
Agricultural and Biological Sciences 10 11%
Nursing and Health Professions 6 6%
Mathematics 4 4%
Immunology and Microbiology 3 3%
Other 16 17%
Unknown 33 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2022.
All research outputs
#1,744,445
of 23,940,793 outputs
Outputs from BMC Infectious Diseases
#454
of 8,020 outputs
Outputs of similar age
#24,682
of 368,259 outputs
Outputs of similar age from BMC Infectious Diseases
#11
of 193 outputs
Altmetric has tracked 23,940,793 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,020 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 368,259 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 193 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.