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The clinical and public health problem of relapse despite primaquine therapy: case review of repeated relapses of Plasmodium vivax acquired in Papua New Guinea

Overview of attention for article published in Malaria Journal, December 2014
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Citations

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77 Mendeley
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Title
The clinical and public health problem of relapse despite primaquine therapy: case review of repeated relapses of Plasmodium vivax acquired in Papua New Guinea
Published in
Malaria Journal, December 2014
DOI 10.1186/1475-2875-13-488
Pubmed ID
Authors

R Joan H Ingram, Chelzie Crenna-Darusallam, Saraswati Soebianto, Rintis Noviyanti, J Kevin Baird

Abstract

Primaquine is the only drug available for preventing relapse following a primary attack by Plasmodium vivax malaria. This drug imposes several important problems: daily dosing over two weeks; toxicity in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency; partner blood schizontocides possibly impacting primaquine safety and efficacy; cytochrome P-450 abnormalities impairing metabolism and therapeutic activity; and some strains of parasite may be tolerant or resistant to primaquine. There are many possible causes of repeated relapses in a patient treated with primaquine.

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Tanzania, United Republic of 1 1%
Brazil 1 1%
Unknown 74 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 25%
Lecturer 8 10%
Student > Master 7 9%
Student > Bachelor 7 9%
Student > Ph. D. Student 6 8%
Other 16 21%
Unknown 14 18%
Readers by discipline Count As %
Medicine and Dentistry 24 31%
Biochemistry, Genetics and Molecular Biology 8 10%
Nursing and Health Professions 6 8%
Immunology and Microbiology 6 8%
Agricultural and Biological Sciences 5 6%
Other 12 16%
Unknown 16 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2014.
All research outputs
#7,544,526
of 8,701,761 outputs
Outputs from Malaria Journal
#2,769
of 3,065 outputs
Outputs of similar age
#195,061
of 242,714 outputs
Outputs of similar age from Malaria Journal
#88
of 100 outputs
Altmetric has tracked 8,701,761 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,065 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,714 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.