Title |
Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53
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Published in |
Molecular Neurodegeneration, December 2014
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DOI | 10.1186/1750-1326-9-56 |
Pubmed ID | |
Authors |
Silvia Rossi, Caterina Motta, Valeria Studer, Giulia Macchiarulo, Elisabetta Volpe, Francesca Barbieri, Gabriella Ruocco, Fabio Buttari, Annamaria Finardi, Raffaele Mancino, Sagit Weiss, Luca Battistini, Gianvito Martino, Roberto Furlan, Jelena Drulovic, Diego Centonze |
Abstract |
Understanding how inflammation causes neuronal damage is of paramount importance in multiple sclerosis (MS) and in other neurodegenerative diseases. Here we addressed the role of the apoptotic cascade in the synaptic abnormalities and neuronal loss caused by the proinflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor (TNF-α) in brain tissues, and disease progression caused by inflammation in relapsing-remitting MS (RRMS) patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Unknown | 96 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 18 | 19% |
Student > Ph. D. Student | 15 | 15% |
Researcher | 9 | 9% |
Other | 8 | 8% |
Student > Master | 8 | 8% |
Other | 16 | 16% |
Unknown | 23 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 16 | 16% |
Agricultural and Biological Sciences | 13 | 13% |
Medicine and Dentistry | 13 | 13% |
Biochemistry, Genetics and Molecular Biology | 10 | 10% |
Immunology and Microbiology | 5 | 5% |
Other | 8 | 8% |
Unknown | 32 | 33% |