Title |
Normal mitochondrial respiratory function is essential for spatial remote memory in mice
|
---|---|
Published in |
Molecular Brain, December 2008
|
DOI | 10.1186/1756-6606-1-21 |
Pubmed ID | |
Authors |
Daisuke Tanaka, Kazuto Nakada, Keizo Takao, Emi Ogasawara, Atsuko Kasahara, Akitsugu Sato, Hiromichi Yonekawa, Tsuyoshi Miyakawa, Jun-Ichi Hayashi |
Abstract |
Mitochondrial DNA (mtDNA) with pathogenic mutations has been found in patients with cognitive disorders. However, little is known about whether pathogenic mtDNA mutations and the resultant mitochondrial respiration deficiencies contribute to the expression of cognitive alterations, such as impairments of learning and memory. To address this point, we used two groups of trans-mitochondrial mice (mito-mice) with heteroplasmy for wild-type and pathogenically deleted (Δ) mtDNA; the "low" group carried 50% or less ΔmtDNA, and the "high" group carried more than 50% ΔmtDNA. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | 4% |
United Kingdom | 1 | 2% |
Singapore | 1 | 2% |
Switzerland | 1 | 2% |
Unknown | 45 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 8 | 16% |
Researcher | 8 | 16% |
Student > Ph. D. Student | 6 | 12% |
Other | 4 | 8% |
Student > Master | 4 | 8% |
Other | 9 | 18% |
Unknown | 11 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 20% |
Biochemistry, Genetics and Molecular Biology | 8 | 16% |
Medicine and Dentistry | 8 | 16% |
Neuroscience | 7 | 14% |
Psychology | 2 | 4% |
Other | 3 | 6% |
Unknown | 12 | 24% |