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Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2

Overview of attention for article published in BMC Biology, November 2017
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Title
Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2
Published in
BMC Biology, November 2017
DOI 10.1186/s12915-017-0452-9
Pubmed ID
Authors

Wei L. Hsu, Yun L. Ma, Yen C. Liu, Eminy H. Y. Lee

Abstract

Smad4 is a critical effector of TGF-β signaling that regulates a variety of cellular functions. However, its role in the brain has rarely been studied. Here, we examined the molecular mechanisms underlying the post-translational regulation of Smad4 function by SUMOylation, and its role in spatial memory formation. In the hippocampus, Smad4 is SUMOylated by the E3 ligase PIAS1 at Lys-113 and Lys-159. Both spatial training and NMDA injection enhanced Smad4 SUMOylation. Inhibition of Smad4 SUMOylation impaired spatial learning and memory in rats by downregulating TPM2, a gene associated with skeletal myopathies. Similarly, knockdown of TPM2 expression impaired spatial learning and memory, while TPM2 mRNA and protein expression increased after spatial training. Among the TPM2 mutations associated with skeletal myopathies, the TPM2E122K mutation was found to reduce TPM2 expression and impair spatial learning and memory in rats. We have identified a novel role of Smad4 SUMOylation and TPM2 in learning and memory formation. These results suggest that patients with skeletal myopathies who carry the TPM2E122K mutation may also have deficits in learning and memory functions.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 25%
Student > Doctoral Student 1 13%
Lecturer 1 13%
Student > Bachelor 1 13%
Other 1 13%
Other 0 0%
Unknown 2 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 38%
Biochemistry, Genetics and Molecular Biology 2 25%
Design 1 13%
Unknown 2 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2019.
All research outputs
#12,292,037
of 16,119,223 outputs
Outputs from BMC Biology
#1,267
of 1,389 outputs
Outputs of similar age
#274,387
of 412,738 outputs
Outputs of similar age from BMC Biology
#120
of 127 outputs
Altmetric has tracked 16,119,223 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,389 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.8. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
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We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.