Title |
Creating groups with similar expected behavioural response in randomized controlled trials: a fuzzy cognitive map approach
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Published in |
BMC Medical Research Methodology, December 2014
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DOI | 10.1186/1471-2288-14-130 |
Pubmed ID | |
Authors |
Philippe J Giabbanelli, Rik Crutzen |
Abstract |
Controlling bias is key to successful randomized controlled trials for behaviour change. Bias can be generated at multiple points during a study, for example, when participants are allocated to different groups. Several methods of allocations exist to randomly distribute participants over the groups such that their prognostic factors (e.g., socio-demographic variables) are similar, in an effort to keep participants' outcomes comparable at baseline. Since it is challenging to create such groups when all prognostic factors are taken together, these factors are often balanced in isolation or only the ones deemed most relevant are balanced. However, the complex interactions among prognostic factors may lead to a poor estimate of behaviour, causing unbalanced groups at baseline, which may introduce accidental bias. |
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