Title |
Genotyping of Plasmodium falciparum using antigenic polymorphic markers and to study anti-malarial drug resistance markers in malaria endemic areas of Bangladesh
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Published in |
Malaria Journal, November 2012
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DOI | 10.1186/1475-2875-11-386 |
Pubmed ID | |
Authors |
Jasmin Akter, Kamala Thriemer, Wasif A Khan, David J Sullivan, Harald Noedl, Rashidul Haque |
Abstract |
In the past many regions of Bangladesh were hyperendemic for malaria. Malaria control in the 1960s to 1970s eliminated malaria from the plains but in the Chittagong Hill Tracts remained a difficult to control reservoir. The Chittagong Hill Tracts have areas with between 1 and 10% annual malaria rates, predominately 90-95% Plasmodium falciparum. In Southeast Asia, multiplicity of infection for hypo-endemic regions has been approximately 1.5. Few studies on the genetic diversity of P. falciparum have been performed in Bangladesh. Anderson et al. performed a study in Khagrachari, northern Chittagong Hill Tracts in 2002 on 203 patients and found that parasites had a multiplicity of infection of 1.3 by MSP-1, MSP-2 and GLURP genotyping. A total of 94% of the isolates had the K76T Pfcrt chloroquine resistant genotype, and 70% showed the N86Y Pfmdr1 genotype. Antifolate drug resistant genotypes were high with 99% and 73% of parasites having two or more mutations at the dhfr or dhps loci. |
X Demographics
Geographical breakdown
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Egypt | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 3% |
Burkina Faso | 1 | 1% |
Unknown | 68 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 20 | 28% |
Student > Master | 10 | 14% |
Student > Ph. D. Student | 8 | 11% |
Student > Bachelor | 5 | 7% |
Student > Doctoral Student | 4 | 6% |
Other | 11 | 15% |
Unknown | 13 | 18% |
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Medicine and Dentistry | 7 | 10% |
Nursing and Health Professions | 3 | 4% |
Immunology and Microbiology | 3 | 4% |
Other | 9 | 13% |
Unknown | 15 | 21% |