Title |
Human umbilical endothelial cells (HUVECs) have a sex: characterisation of the phenotype of male and female cells
|
---|---|
Published in |
Biology of Sex Differences, December 2014
|
DOI | 10.1186/s13293-014-0018-2 |
Pubmed ID | |
Authors |
Roberta Addis, Ilaria Campesi, Marco Fois, Giampiero Capobianco, Salvatore Dessole, Grazia Fenu, Andrea Montella, Maria Grazia Cattaneo, Lucia M Vicentini, Flavia Franconi |
Abstract |
Human umbilical endothelial cells (HUVECs) are widely used to study the endothelial physiology and pathology that might be involved in sex and gender differences detected at the cardiovascular level. This study evaluated whether HUVECs are sexually dimorphic in their morphological, proliferative and migratory properties and in the gene and protein expression of oestrogen and androgen receptors and nitric oxide synthase 3 (NOS3). Moreover, because autophagy is influenced by sex, its degree was analysed in male and female HUVECs (MHUVECs and FHUVECs). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Malaysia | 1 | <1% |
Spain | 1 | <1% |
Switzerland | 1 | <1% |
Unknown | 116 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 27 | 23% |
Student > Bachelor | 16 | 13% |
Student > Master | 14 | 12% |
Researcher | 12 | 10% |
Student > Doctoral Student | 10 | 8% |
Other | 14 | 12% |
Unknown | 26 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 16% |
Biochemistry, Genetics and Molecular Biology | 18 | 15% |
Agricultural and Biological Sciences | 14 | 12% |
Engineering | 10 | 8% |
Immunology and Microbiology | 5 | 4% |
Other | 21 | 18% |
Unknown | 32 | 27% |