Title |
Glycosuria medicated with ipragliflozin and nifedipine or ipragliflozin and candesartan: a case report
|
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Published in |
Journal of Medical Case Reports, December 2014
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DOI | 10.1186/1752-1947-8-428 |
Pubmed ID | |
Authors |
Shuichi Okada, Ryo Shibusawa, Yuko Tagaya, Tsugumichi Saito, Eijiro Yamada, Yoko Shimoda, Tetsurou Satoh, Junichi Okada, Masanobu Yamada |
Abstract |
Animal studies have reported that treatment with angiotensin II receptor blockers reduced kidney sodium-dependent glucose cotransporter expression. We therefore hypothesized that patients with hypertension treated with an angiotensin II receptor blocker (candesartan) would probably have an increased response to sodium-dependent glucose cotransporter inhibitor therapy (ipragliflozin) compared with patients treated with alternative hypertensive medications such as calcium channel blockers (nifedipine).Although sodium-dependent glucose cotransporter inhibitor (ipragliflozin) is a new anti-diabetic medicine, the clinical efficacy in the Japanese population has not been fully evaluated. We compared the combined effect of angiotensin II receptor blocker candesartan plus ipragliflozin with nifedipine plus ipragliflozin therapy and found that the combination of candesartan plus ipragliflozin was more effective in increasing glycosuria and lowering plasma glucose. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 25% |
Student > Doctoral Student | 2 | 17% |
Student > Bachelor | 1 | 8% |
Researcher | 1 | 8% |
Professor > Associate Professor | 1 | 8% |
Other | 0 | 0% |
Unknown | 4 | 33% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 33% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Engineering | 1 | 8% |
Unknown | 4 | 33% |