Title |
Chasing the precursor of functional hematopoietic stem cells at the single cell levels in mouse embryos
|
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Published in |
Journal of Hematology & Oncology, July 2016
|
DOI | 10.1186/s13045-016-0289-7 |
Pubmed ID | |
Authors |
Xiaochen Wang, Yuemin Gong, Hideo Ema |
Abstract |
Adult hematopoietic stem cells (HSCs), the ideal system for regenerative research, were isolated at single cell levels decades ago, whereas studies on embryonic HSCs are much more difficult. Zhou et al identified a new pre-HSC cell surface marker, CD201, by which they isolated pre-HSCs at single cell levels for further analyses. The novel expression pattern of HSC development is revealed, including the fundamental role of mammalian targets of rapamycin (mTOR) signaling pathway in HSCs emergence, and the repopulation potential of S/G2/M phase pre-HSCs. Deeper understandings of the cellular origin and developmental regulatory network of HSCs are essential to develop new strategies of generating HSCs in vitro for clinical application. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Hungary | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 4% |
Unknown | 27 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 21% |
Student > Bachelor | 4 | 14% |
Researcher | 4 | 14% |
Student > Master | 3 | 11% |
Professor | 2 | 7% |
Other | 5 | 18% |
Unknown | 4 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 39% |
Medicine and Dentistry | 4 | 14% |
Agricultural and Biological Sciences | 2 | 7% |
Immunology and Microbiology | 2 | 7% |
Unspecified | 1 | 4% |
Other | 3 | 11% |
Unknown | 5 | 18% |