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Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes

Overview of attention for article published in Nutrition & Metabolism, December 2014
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Title
Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes
Published in
Nutrition & Metabolism, December 2014
DOI 10.1186/1743-7075-11-55
Pubmed ID
Authors

Xiaoqin Luo, Lei Xiao, Haixia Yang, Ruijuan Zhang, Manli Jiang, Jiahua Ni, Ting Lei, Nanping Wang

Abstract

Hyperhomocysteinemia (HHcy) is an independent risk factor for liver diseases, such as fatty liver and hepatic fibrosis. However, the mechanisms underlying this pro-oxidative effect of homocysteine (Hcy) in hepatocytes remain largely unknown. Thus, we investigated the effect of Hcy on the gene expression of heme oxygenase-1 (HO-1), the primary rate-limiting enzyme in heme catabolism and a key anti-oxidant detoxification enzyme in maintaining cellular redox homeostasis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 26%
Student > Master 3 13%
Professor 2 9%
Student > Postgraduate 2 9%
Student > Doctoral Student 1 4%
Other 4 17%
Unknown 5 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 26%
Agricultural and Biological Sciences 3 13%
Neuroscience 2 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Medicine and Dentistry 1 4%
Other 3 13%
Unknown 7 30%