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Mendeley readers
Title |
Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes
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Published in |
Nutrition & Metabolism, December 2014
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DOI | 10.1186/1743-7075-11-55 |
Pubmed ID | |
Authors |
Xiaoqin Luo, Lei Xiao, Haixia Yang, Ruijuan Zhang, Manli Jiang, Jiahua Ni, Ting Lei, Nanping Wang |
Abstract |
Hyperhomocysteinemia (HHcy) is an independent risk factor for liver diseases, such as fatty liver and hepatic fibrosis. However, the mechanisms underlying this pro-oxidative effect of homocysteine (Hcy) in hepatocytes remain largely unknown. Thus, we investigated the effect of Hcy on the gene expression of heme oxygenase-1 (HO-1), the primary rate-limiting enzyme in heme catabolism and a key anti-oxidant detoxification enzyme in maintaining cellular redox homeostasis. |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 26% |
Student > Master | 3 | 13% |
Professor | 2 | 9% |
Student > Postgraduate | 2 | 9% |
Student > Doctoral Student | 1 | 4% |
Other | 4 | 17% |
Unknown | 5 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 26% |
Agricultural and Biological Sciences | 3 | 13% |
Neuroscience | 2 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Medicine and Dentistry | 1 | 4% |
Other | 3 | 13% |
Unknown | 7 | 30% |