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Borderline pulmonary arterial pressure in systemic sclerosis patients: a post-hoc analysis of the DETECT study

Overview of attention for article published in Arthritis Research & Therapy, December 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

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Title
Borderline pulmonary arterial pressure in systemic sclerosis patients: a post-hoc analysis of the DETECT study
Published in
Arthritis Research & Therapy, December 2014
DOI 10.1186/s13075-014-0493-1
Pubmed ID
Authors

Scott H Visovatti, Oliver Distler, J Gerry Coghlan, Christopher P Denton, Ekkehard Grünig, Diana Bonderman, Ulf Müller-Ladner, Janet E Pope, Madelon C Vonk, James R Seibold, Juan-Vicente Torres-Martin, Martin Doelberg, Harbajan Chadha-Boreham, Daniel M Rosenberg, Vallerie V McLaughlin, Dinesh Khanna

Abstract

IntroductionPatients with mean pulmonary artery pressures (mPAP) of 21 to 24 mm Hg have a so-called borderline elevation of mPAP (BoPAP)¿a condition thought to represent early-stage pulmonary arterial vasculopathy. Based on the DETECT study, this post-hoc analysis examined patient characteristics of systemic sclerosis (SSc) patients with normal mPAP, BoPAP and elevated mPAP, fulfilling pulmonary arterial hypertension (PAH) criteria.MethodsAdult patients with a duration of SSc more than 3 years, a diffusing capacity of the lung for carbon monoxide less than 60% predicted, and no previous diagnosis of any form of pulmonary hypertension (PH) underwent screening tests followed by right heart catheterization. Subjects were divided into three groups: normal mPAP, BoPAP, and PAH. Exploratory comparative and binary logistic regression analyses were performed for the BoPAP versus normal mPAP and PAH versus BoPAP groups.ResultsOf 244 patients evaluated, 148 (60%) had normal mPAP, 36 (15%) had BoPAP, and 60 (25%) had definite PAH. Univariable logistic regression (ULR) showed the mean tricuspid regurgitation velocity in patients with BoPAP to be intermediate between normal mPAP and PAH. In the ULR analyses BoPAP versus normal mPAP and PAH versus BoPAP, the statistically significant predictors were, amongst others: demographic, clinical, pulmonary function, echocardiographic and hemodynamic variables.ConclusionsIn this exploratory post-hoc analysis of the DETECT study population patients with BoPAP could be distinguished from patients with normal mPAP and PAH, and it appears that BoPAP may be an intermediate stage on the continuum between normal PA pressures and PAH.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Other 11 23%
Researcher 7 15%
Student > Bachelor 5 10%
Student > Postgraduate 5 10%
Student > Doctoral Student 2 4%
Other 9 19%
Unknown 9 19%
Readers by discipline Count As %
Medicine and Dentistry 29 60%
Immunology and Microbiology 3 6%
Agricultural and Biological Sciences 2 4%
Nursing and Health Professions 2 4%
Social Sciences 1 2%
Other 1 2%
Unknown 10 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2015.
All research outputs
#3,798,066
of 25,371,288 outputs
Outputs from Arthritis Research & Therapy
#901
of 3,380 outputs
Outputs of similar age
#51,634
of 368,276 outputs
Outputs of similar age from Arthritis Research & Therapy
#10
of 58 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 368,276 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.