Title |
Efficacy of intranasal administration of artesunate in experimental cerebral malaria
|
---|---|
Published in |
Malaria Journal, December 2014
|
DOI | 10.1186/1475-2875-13-501 |
Pubmed ID | |
Authors |
Anne Marijon, Guillaume Bonnot, Anthony Fourier, Coralie Bringer, Adeline Lavoignat, Marie-Claude Gagnieu, Anne-Lise Bienvenu, Stéphane Picot |
Abstract |
Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas. Intravenous artesunate is currently the first-line treatment, but the lack of material and skills in the field make it difficult to implement in endemic areas. Intranasal route provides a very easy and direct gateway to blood and brain to deliver medications, by-passing the brain blood barrier. Therefore, it could be helpful and suitable to administer artesunate in the context of cerebral malaria, especially in young children. In this study, intranasal administration of artesunate to rescue from cerebral malaria using a murine model was tested. |
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Mendeley readers
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