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The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist

Overview of attention for article published in BMC Research Notes, January 2014
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1 tweeter

Citations

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Title
The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist
Published in
BMC Research Notes, January 2014
DOI 10.1186/1756-0500-7-913
Pubmed ID
Authors

Anne Müller, Brinja Leinweber, Jana Fischer, Timo D Müller, Annette Grüters, Matthias H Tschöp, Vera Knäuper, Heike Biebermann, Gunnar Kleinau

Abstract

Recently, the orphan G-protein coupled receptor 83 (GPR83) was identified as a new participant in body weight regulation. This receptor is highly expressed in the hypothalamic arcuate nucleus and is regulated in response to nutrient availability. Gpr83 knock-out mice are protected from diet-induced obesity. Moreover, in a previous study, we designed and characterized several artificial constitutively activating mutations (CAMs) in GPR83. A particular CAM was located in the extracellular N-terminal domain (eNDo) that is highly conserved among GPR83 orthologs. This suggests the contribution of this receptor part into regulation of signaling, which needed a more detailed investigation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 2 13%
United States 1 7%
Unknown 12 80%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 33%
Student > Ph. D. Student 4 27%
Student > Master 2 13%
Student > Bachelor 1 7%
Other 1 7%
Other 2 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 33%
Medicine and Dentistry 2 13%
Neuroscience 2 13%
Computer Science 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Other 4 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2014.
All research outputs
#8,959,111
of 11,214,196 outputs
Outputs from BMC Research Notes
#1,711
of 2,458 outputs
Outputs of similar age
#170,512
of 252,572 outputs
Outputs of similar age from BMC Research Notes
#67
of 94 outputs
Altmetric has tracked 11,214,196 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,458 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,572 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.