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Binding site of restriction-modification system controller protein in Mollicutes

Overview of attention for article published in BMC Microbiology, January 2017
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Title
Binding site of restriction-modification system controller protein in Mollicutes
Published in
BMC Microbiology, January 2017
DOI 10.1186/s12866-017-0935-4
Pubmed ID
Authors

Gleb Y. Fisunov, Daria V. Evsyutina, Valentin A. Manuvera, Vadim M. Govorun

Abstract

Bacteria of the class Mollicutes underwent extreme reduction of genomes and gene expression control systems. Only a few regulators are known to date. In this work, we describe a novel group of transcriptional regulators that are distributed within different Mollicutes and control the expression of restriction-modification systems (RM-systems). We performed cross-species search of putative regulators of RM-systems (C-proteins) and respective binding sites in Mollicutes. We identified a set of novel putative C-protein binding motifs distributed within Mollicutes. We studied the most frequent motif and respective C-protein on the model of Mycoplasma gallisepticum S6. We confirmed our prediction and identified key nucleotides important for C-protein binding. Further we identified novel target promoters of C-protein in M. gallisepticum. We found that C-protein of M. gallisepticum binds predicted conserved direct repeats of the (GTGTTAN5)2 motif. Apart from its own operon promoter, HsdC can bind to the promoters of the clpB chaperone gene and a tRNA cluster.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 23%
Student > Ph. D. Student 5 23%
Student > Doctoral Student 3 14%
Student > Master 3 14%
Student > Postgraduate 2 9%
Other 0 0%
Unknown 4 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 36%
Biochemistry, Genetics and Molecular Biology 5 23%
Immunology and Microbiology 3 14%
Business, Management and Accounting 1 5%
Unknown 5 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2017.
All research outputs
#10,855,154
of 12,247,570 outputs
Outputs from BMC Microbiology
#1,432
of 1,761 outputs
Outputs of similar age
#283,711
of 341,879 outputs
Outputs of similar age from BMC Microbiology
#47
of 65 outputs
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So far Altmetric has tracked 1,761 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.