Title |
Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat
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Published in |
Veterinary Research, December 2014
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DOI | 10.1186/s13567-014-0127-2 |
Pubmed ID | |
Authors |
Qunhui Li, Xuan Wang, Min Gu, Jie Zhu, Xiaoli Hao, Zhao Gao, Zhongtao Sun, Jiao Hu, Shunlin Hu, Xiaoquan Wang, Xiaowen Liu, Xiufan Liu |
Abstract |
The emerging H5 clade 2.3.4.6 viruses of different NA subtypes have been detected in different domestic poultry in China. We evaluated the receptor binding property and transmissibility of four novel H5 clade 2.3.4.6 subtype highly pathogenic avian influenza viruses. The results show that these viruses bound to both avian-type (α-2,3) and human-type (α-2,6) receptors. Furthermore, we found that one of these viruses, GS/EC/1112/11, not only replicated but also transmitted efficiently in guinea pigs. Therefore, such novel H5 subtype viruses have the potential of a pandemic threat. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 20% |
United States | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 4% |
China | 1 | 4% |
Unknown | 23 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 28% |
Researcher | 6 | 24% |
Professor | 3 | 12% |
Student > Master | 2 | 8% |
Other | 1 | 4% |
Other | 3 | 12% |
Unknown | 3 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 32% |
Medicine and Dentistry | 4 | 16% |
Immunology and Microbiology | 3 | 12% |
Veterinary Science and Veterinary Medicine | 2 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Other | 3 | 12% |
Unknown | 4 | 16% |