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Status of benzimidazole resistance in intestinal nematode populations of livestock in Brazil: a systematic review

Overview of attention for article published in BMC Veterinary Research, November 2017
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Title
Status of benzimidazole resistance in intestinal nematode populations of livestock in Brazil: a systematic review
Published in
BMC Veterinary Research, November 2017
DOI 10.1186/s12917-017-1282-2
Pubmed ID
Authors

Lauren Hubert Jaeger, Filipe Anibal Carvalho-Costa

Abstract

Benzimidazoles (BZ) are a class of drugs widely used in veterinary and human medicine, creating a great selection pressure and the emergence of BZ resistance. We conducted a systematic review to assess the status of resistance and/or effectiveness reduction of BZ drugs in animal nematodes in Brazil, and make information accessible to the scientific community, as many studies are published in Portuguese. PubMed, SciELO Brasil, LILACS/Bireme, GNTD database, and Google Scholar were searched with no language restrictions. A total of 40 studies met our eligibility criteria (from the year 1989 forward). Sheep was the host most frequently analysed, and albendazole was the most frequently drug studied. The majority of studies (75.7%) showed that BZ drugs are insufficiently active (FECRT <80%) against nematode parasites of livestock. The mean FECRT for fenbendazole, thiabendazole, albendazole, mebendazole, oxfendazole, and ricobendazole were 71.8%, 71.8%, 58.6%, 53.9%, 46.9%, and 41.5%, respectively. It was observed through linear regression that FECRT is significantly reduced over time between 2007 and 2014 (R = -0.653 p = 0.021) for the treatment of cattle with BZ, suggesting progressive loss of effectiveness and increased resistance for these hosts. The scenario of BZ resistance in nematode populations in Brazil is not favourable. Given the high cost of drug discovery and development, it is urgent to implement control measures and to monitor the effectiveness/resistance to nematodes in livestock in Brazil.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 72 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 15%
Student > Bachelor 8 11%
Researcher 8 11%
Student > Doctoral Student 6 8%
Other 6 8%
Other 9 13%
Unknown 24 33%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 11 15%
Medicine and Dentistry 9 13%
Agricultural and Biological Sciences 9 13%
Chemistry 5 7%
Biochemistry, Genetics and Molecular Biology 4 6%
Other 9 13%
Unknown 25 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2017.
All research outputs
#17,921,555
of 23,009,818 outputs
Outputs from BMC Veterinary Research
#1,690
of 3,065 outputs
Outputs of similar age
#305,737
of 438,191 outputs
Outputs of similar age from BMC Veterinary Research
#58
of 90 outputs
Altmetric has tracked 23,009,818 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,065 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
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We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.