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ACTA2 mutation and postpartum hemorrhage: a case report

Overview of attention for article published in BMC Medical Genetics, December 2017
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1 tweeter

Citations

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18 Mendeley
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Title
ACTA2 mutation and postpartum hemorrhage: a case report
Published in
BMC Medical Genetics, December 2017
DOI 10.1186/s12881-017-0505-5
Pubmed ID
Authors

Kylie Cooper, Stephen Brown

Abstract

ACTA2 encodes smooth muscle specific α-actin, a critical component or the contractile complex of vascular smooth muscle. Mutations in ACTA2 are the most common genetic cause of thoracic aortic aneurysm, and are also the cause of other disorders, including Moyamoya disease, coronary artery disease and stroke as well as Multisystemic Smooth Muscle Dysfunction Syndrome. We note that ACTA2 is also expressed in uterine smooth muscle, and this raises the possibility that women harboring ACTA2 mutations might exhibit uterine smooth muscle dysfunction. We present a young woman whose ACTA2 mutation was ascertained during pregnancy because of her father's history of dissecting aneurysms. She was delivered at full term by cesarean section and subsequently had severe uterine hemorrhage due to uterine atony. Although her atony was successfully treated with uterotonic medications, she required blood transfusion. This case raises the possibility that women with ACTA2 mutations may be at risk of uterine muscle dysfunction and hemorrhage. Obstetricians should be alerted to and prepared for this possibility.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 22%
Other 3 17%
Student > Ph. D. Student 2 11%
Student > Bachelor 1 6%
Researcher 1 6%
Other 0 0%
Unknown 7 39%
Readers by discipline Count As %
Medicine and Dentistry 7 39%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Agricultural and Biological Sciences 1 6%
Nursing and Health Professions 1 6%
Unknown 8 44%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2017.
All research outputs
#9,790,349
of 12,253,439 outputs
Outputs from BMC Medical Genetics
#472
of 721 outputs
Outputs of similar age
#244,651
of 341,983 outputs
Outputs of similar age from BMC Medical Genetics
#24
of 56 outputs
Altmetric has tracked 12,253,439 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 721 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
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We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.