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Mitogen-activated protein kinase Hog1 is activated in response to curcumin exposure in the budding yeast Saccharomyces cerevisiae

Overview of attention for article published in BMC Microbiology, December 2014
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Title
Mitogen-activated protein kinase Hog1 is activated in response to curcumin exposure in the budding yeast Saccharomyces cerevisiae
Published in
BMC Microbiology, December 2014
DOI 10.1186/s12866-014-0317-0
Pubmed ID
Authors

Gajendra Kumar Azad, Vikash Singh, Mayur Jankiram Thakare, Shivani Baranwal, Raghuvir Singh Tomar

Abstract

BackgroundCurcumin (CUR), an active polyphenol derived from the spice turmeric, has been traditionally used for centuries in ancient Indian medicine to treat a number of diseases. The physiological effects of CUR have been shown to be diverse; however, the target molecules and pathways that CUR affects have yet to be fully described.ResultsHere, we demonstrate for the first time that the budding yeast mitogen-activated protein kinase (MAPK) Hog1 is essential for the response to CUR. Moreover, CUR-induced Hog1 phosphorylation was rescued by supplementation of iron to the growth medium. Hog1 was rapidly phosphorylated upon CUR treatment, but unlike the response to hyperosmotic shock (0.8 M NaCl), it remains activated for an extended period of time. A detailed analysis of HOG pathway mutants revealed that Pbs2p, Ptc2p, and Ssk2p are required for optimal CUR-induced Hog1 phosphorylation. We also observed a Hog1 dependent transcriptional response to CUR treatment that involved the up-regulation of glycerol-3-phosphate dehydrogenase 1 (GPD1), a factor that is essential for the hyperosmotic stress response.ConclusionsOur present finding revealed the role of Hog1 MAPK in regulation of CUR-induced transcriptional response. We anticipate that our finding will enhance the understanding on the molecular mode of action of CUR on S. cerevisiae.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 17%
Student > Master 3 13%
Researcher 3 13%
Student > Bachelor 3 13%
Student > Doctoral Student 2 8%
Other 2 8%
Unknown 7 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 25%
Biochemistry, Genetics and Molecular Biology 4 17%
Medicine and Dentistry 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Environmental Science 1 4%
Other 2 8%
Unknown 7 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2015.
All research outputs
#18,387,239
of 22,775,504 outputs
Outputs from BMC Microbiology
#2,237
of 3,184 outputs
Outputs of similar age
#255,848
of 353,125 outputs
Outputs of similar age from BMC Microbiology
#36
of 53 outputs
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We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.