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Interest of preoperative immunonutrition in liver resection for cancer: study protocol of the PROPILS trial, a multicenter randomized controlled phase IV trial

Overview of attention for article published in BMC Cancer, December 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

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5 tweeters
facebook
1 Facebook page

Citations

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25 Dimensions

Readers on

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179 Mendeley
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Title
Interest of preoperative immunonutrition in liver resection for cancer: study protocol of the PROPILS trial, a multicenter randomized controlled phase IV trial
Published in
BMC Cancer, December 2014
DOI 10.1186/1471-2407-14-980
Pubmed ID
Authors

Oriana Ciacio, Thibault Voron, Gabriella Pittau, Maité Lewin, Eric Vibert, René Adam, Antonio Sa Cunha, Daniel Cherqui, Astrid Schielke, Olivier Soubrane, Olivier Scatton, Chady Salloum, Daniel Azoulay, Stéphane Benoist, Perrine Goyer, Jean-Christophe Vaillant, Laurent Hannoun, Emmanuel Boleslawski, Hélène Agostini, Didier Samuel, Denis Castaing

Abstract

Malnutrition is an independent risk factor of postoperative morbidity and mortality and it's observed in 20 to 50% of surgical patients. Preoperative interventions to optimize the nutritional status, reduce postoperative complications and enteral nutrition has proven to be superior to the parenteral one. Moreover, regardless of the nutritional status of the patient, surgery impairs the immunological response, thus increasing the risk of postoperative sepsis. Immunonutrition has been developed to improve the immunometabolic host response in perioperative period and it has been proven to reduce significantly postoperative infectious complications and length of hospital stay in patients undergoing elective gastrointestinal surgery for tumors. We hypothesize that a preoperative oral immunonutrition (ORAL IMPACT(R)) can reduce postoperative morbidity in liver resection for cancer.Methods/design: Prospective multicenter randomized placebo-controlled double-blind phase IV trial with two parallel treatment groups receiving either study product (ORAL IMPACT(R)) or control supplement (isocaloric isonitrogenous supplement - IMPACT CONTROL(R)) for 7 days before liver resection for cancer. A total of 400 patients will be enrolled. Patients will be stratified according to the type of hepatectomy, the presence of chronic liver disease and the investigator center. The main end-point is to evaluate in intention-to-treat analysis the overall 30-day morbidity. Secondary end-points are to assess the 30-day infectious and non-infectious morbidity, length of antibiotic treatment and hospital stay, modifications on total food intake, compliance to treatment, side-effects of immunonutrition, impact on liver regeneration and sarcopenia, and to perform a medico-economic analysis.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 179 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
United States 1 <1%
Unknown 177 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 26 15%
Student > Master 21 12%
Student > Ph. D. Student 18 10%
Student > Postgraduate 16 9%
Student > Bachelor 16 9%
Other 44 25%
Unknown 38 21%
Readers by discipline Count As %
Medicine and Dentistry 76 42%
Nursing and Health Professions 14 8%
Agricultural and Biological Sciences 7 4%
Biochemistry, Genetics and Molecular Biology 6 3%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Other 17 9%
Unknown 54 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2015.
All research outputs
#2,252,024
of 5,428,610 outputs
Outputs from BMC Cancer
#742
of 2,879 outputs
Outputs of similar age
#67,423
of 188,248 outputs
Outputs of similar age from BMC Cancer
#39
of 146 outputs
Altmetric has tracked 5,428,610 research outputs across all sources so far. This one has received more attention than most of these and is in the 56th percentile.
So far Altmetric has tracked 2,879 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 188,248 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 146 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.