Title |
Intratumoral heterogeneity in a minority of ovarian low-grade serous carcinomas
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Published in |
BMC Cancer, December 2014
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DOI | 10.1186/1471-2407-14-982 |
Pubmed ID | |
Authors |
Alicia A Tone, Melissa K McConechy, Winnie Yang, Jiarui Ding, Stephen Yip, Esther Kong, Kwong-Kwok Wong, David M Gershenson, Helen Mackay, Sohrab Shah, Blake Gilks, Anna V Tinker, Blaise Clarke, Jessica N McAlpine, David Huntsman |
Abstract |
Ovarian low-grade serous carcinoma (LGSC) has fewer mutations than ovarian high-grade serous carcinoma (HGSC) and a less aggressive clinical course. However, an overwhelming majority of LGSC patients do not respond to conventional chemotherapy resulting in a poor long-term prognosis comparable to women diagnosed with HGSC. KRAS and BRAF mutations are common in LGSC, leading to clinical trials targeting the MAPK pathway. We assessed the stability of targetable somatic mutations over space and/or time in LGSC, with a view to inform stratified treatment strategies and clinical trial design. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 15% |
Other | 7 | 13% |
Researcher | 7 | 13% |
Student > Bachelor | 5 | 9% |
Student > Doctoral Student | 5 | 9% |
Other | 9 | 17% |
Unknown | 13 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 31% |
Biochemistry, Genetics and Molecular Biology | 7 | 13% |
Agricultural and Biological Sciences | 5 | 9% |
Neuroscience | 2 | 4% |
Computer Science | 2 | 4% |
Other | 8 | 15% |
Unknown | 13 | 24% |