Title |
Evolution and comparative analysis of the MHC Class III inflammatory region
|
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Published in |
BMC Genomics, November 2006
|
DOI | 10.1186/1471-2164-7-281 |
Pubmed ID | |
Authors |
Janine E Deakin, Anthony T Papenfuss, Katherine Belov, Joseph GR Cross, Penny Coggill, Sophie Palmer, Sarah Sims, Terence P Speed, Stephan Beck, Jennifer A Marshall Graves |
Abstract |
The Major Histocompatibility Complex (MHC) is essential for immune function. Historically, it has been subdivided into three regions (Class I, II, and III), but a cluster of functionally related genes within the Class III region has also been referred to as the Class IV region or "inflammatory region". This group of genes is involved in the inflammatory response, and includes members of the tumour necrosis family. Here we report the sequencing, annotation and comparative analysis of a tammar wallaby BAC containing the inflammatory region. We also discuss the extent of sequence conservation across the entire region and identify elements conserved in evolution. |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Denmark | 1 | <1% |
Norway | 1 | <1% |
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Researcher | 23 | 22% |
Student > Master | 9 | 9% |
Student > Bachelor | 7 | 7% |
Professor | 6 | 6% |
Other | 17 | 16% |
Unknown | 15 | 14% |
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Computer Science | 2 | 2% |
Other | 8 | 8% |
Unknown | 17 | 16% |