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Genetic variants in antigen presentation-related genes influence susceptibility to hepatitis C virus and viral clearance: a case control study

Overview of attention for article published in BMC Infectious Diseases, December 2014
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Title
Genetic variants in antigen presentation-related genes influence susceptibility to hepatitis C virus and viral clearance: a case control study
Published in
BMC Infectious Diseases, December 2014
DOI 10.1186/s12879-014-0716-8
Pubmed ID
Authors

Peng Huang, Li Dong, Xiaomei Lu, Yuanyuan Zhang, Hongbo Chen, Jie Wang, Yun Zhang, Jing Su, Rongbin Yu

Abstract

BackgroundGenes related to antigen presentation pathway, which are in the non-classical class-II region of human leukocyte antigen (HLA), play a vital role during the infection of hepatitis C virus (HCV).MethodsThe current study determined the genotypes of 34 tagging-SNPs (single nucleotide polymorphisms) from 9 candidate genes (HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, TAP1, TAP2, LMP2, LMP7, and tapasin) in a Chinese population of paid blood donors with high risk of HCV infection. The distributions of those SNPs were compared among the 1207 former paid blood donors with different HCV infection outcomes.Results HLA-DMA rs1063478 and HLA-DOA rs2284191 were independent factors of acquiring HCV infection. Carrying three favorable alleles of rs1063478-T and rs2284191-G offered the highest protective effect (odds ratio¿=¿0.46, 95% confidence intervals¿=¿0.27-0.78). HLA-DOB rs7383287 and LMP2 rs17587 were independent factors of infection chronicity. Subjects carrying two favorable alleles of rs7383287-G and rs17587-A had a decreased risk of HCV chronicity (odds ratio¿=¿0.42, 95% confidence intervals¿=¿0.26-0.66). The interaction analysis showed that experience of plasma donation interacted with the combined effects of rs1063478 and rs2284191 for HCV susceptibility, and the experience of whole blood donation interacted with the association of rs7383287 with HCV clearance.ConclusionsOur results suggested that genetic variants in antigen presentation pathway had influence on susceptibility to HCV infection and viral clearance. HLA-DMA rs1063478, HLA-DOA rs2284191, and HLA-DOB rs7383287 were identified as novel loci in Chinese population that were involved in HCV infection.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 6%
Portugal 1 6%
Australia 1 6%
Unknown 15 83%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 28%
Student > Bachelor 4 22%
Researcher 3 17%
Student > Master 2 11%
Professor > Associate Professor 2 11%
Other 1 6%
Unknown 1 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 44%
Biochemistry, Genetics and Molecular Biology 4 22%
Medicine and Dentistry 3 17%
Social Sciences 1 6%
Unknown 2 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2014.
All research outputs
#3,550,210
of 5,058,381 outputs
Outputs from BMC Infectious Diseases
#2,010
of 2,681 outputs
Outputs of similar age
#120,136
of 179,597 outputs
Outputs of similar age from BMC Infectious Diseases
#127
of 188 outputs
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