Title |
The role of HGF/c-MET signaling pathway in lymphoma
|
---|---|
Published in |
Journal of Hematology & Oncology, December 2016
|
DOI | 10.1186/s13045-016-0366-y |
Pubmed ID | |
Authors |
Bao Quoc Lam, Lu Dai, Zhiqiang Qin |
Abstract |
Inappropriate activation of c-mesenchymal-epithelial transition (MET), the receptor tyrosine kinase (RTK) for hepatocyte growth factor (HGF), has been implicated in tumorigenesis and represented a promising therapeutic target for developing anticancer agents. In contrast to other solid tumors, there are limited data describing the functional role of HGF/c-MET signaling pathway in lymphoma. In the current review, we summarize recent findings about the expression, cellular mechanisms/functions, and therapeutic application of HGF/c-MET in different types of lymphoma, especially B cell lymphoma, T and NK cell lymphoma, and Hodgkin lymphoma. We also discuss the existing problems and future directions about studying the HGF/c-MET pathway in lymphoma cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 49 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 20% |
Researcher | 8 | 16% |
Student > Bachelor | 7 | 14% |
Student > Ph. D. Student | 5 | 10% |
Student > Postgraduate | 3 | 6% |
Other | 5 | 10% |
Unknown | 11 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 20% |
Medicine and Dentistry | 8 | 16% |
Agricultural and Biological Sciences | 7 | 14% |
Chemistry | 4 | 8% |
Veterinary Science and Veterinary Medicine | 2 | 4% |
Other | 2 | 4% |
Unknown | 16 | 33% |