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Postoperative changes of the microbiome: are surgical complications related to the gut flora? A systematic review

Overview of attention for article published in BMC Surgery, December 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

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1 blog
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Title
Postoperative changes of the microbiome: are surgical complications related to the gut flora? A systematic review
Published in
BMC Surgery, December 2017
DOI 10.1186/s12893-017-0325-8
Pubmed ID
Authors

Ann-Kathrin Lederer, Przemyslaw Pisarski, Lampros Kousoulas, Stefan Fichtner-Feigl, Carolin Hess, Roman Huber

Abstract

The purpose of this review was to identify the relationship between the gut microbiome and the development of postoperative complications like anastomotic leakage or a wound infection. Recent reviews focusing on underlying molecular biology suggested that postoperative complications might be influenced by the patients' gut flora. Therefore, a review focusing on the available clinical data is needed. In January 2017 a systematic search was carried out in Medline and WebOfScience to identify all clinical studies, which investigated postoperative complications after gastrointestinal surgery in relation to the microbiome of the gut. Of 337 results 10 studies were included into this analysis after checking for eligibility. In total, the studies comprised 677 patients. All studies reported a postoperative change of the gut flora. In five studies the amount of bacteria decreased to different degrees after surgery, but only one study found a significant reduction. Surgical procedures tended to result in an increase of potentially pathogenic bacteria and a decrease of Lactobacilli and Bifidobacteria. The rate of infectious complications was lower in patients treated with probiotics/symbiotics compared to control groups without a clear relation to the systemic inflammatory response. The treatment with synbiotics/probiotics in addition resulted in faster recovery of bowel movement and a lower rate of postoperative diarrhea and abdominal cramping. There might be a relationship between the gut flora and the development of postoperative complications. Due to methodological shortcomings of the included studies and uncontrolled bias/confounding factors there remains a high level of uncertainty.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 99 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 15%
Other 14 14%
Student > Master 8 8%
Student > Bachelor 8 8%
Professor > Associate Professor 7 7%
Other 20 20%
Unknown 27 27%
Readers by discipline Count As %
Medicine and Dentistry 32 32%
Nursing and Health Professions 12 12%
Agricultural and Biological Sciences 7 7%
Biochemistry, Genetics and Molecular Biology 6 6%
Engineering 3 3%
Other 7 7%
Unknown 32 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2017.
All research outputs
#4,418,587
of 24,885,505 outputs
Outputs from BMC Surgery
#71
of 1,398 outputs
Outputs of similar age
#87,319
of 450,957 outputs
Outputs of similar age from BMC Surgery
#2
of 12 outputs
Altmetric has tracked 24,885,505 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,398 research outputs from this source. They receive a mean Attention Score of 2.0. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,957 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.