Title |
NextGen sequencing reveals short double crossovers contribute disproportionately to genetic diversity in Toxoplasma gondii
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Published in |
BMC Genomics, December 2014
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DOI | 10.1186/1471-2164-15-1168 |
Pubmed ID | |
Authors |
Asis Khan, Jahangheer S Shaik, Michael Behnke, Qiuling Wang, Jitender P Dubey, Hernan A Lorenzi, James W Ajioka, Benjamin M Rosenthal, L David Sibley |
Abstract |
Toxoplasma gondii is a widespread protozoan parasite of animals that causes zoonotic disease in humans. Three clonal variants predominate in North America and Europe, while South American strains are genetically diverse, and undergo more frequent recombination. All three northern clonal variants share a monomorphic version of chromosome Ia (ChrIa), which is also found in unrelated, but successful southern lineages. Although this pattern could reflect a selective advantage, it might also arise from non-Mendelian segregation during meiosis. To understand the inheritance of ChrIa, we performed a genetic cross between the northern clonal type 2 ME49 strain and a divergent southern type 10 strain called VAND, which harbors a divergent ChrIa. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 45 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 28% |
Researcher | 9 | 20% |
Professor > Associate Professor | 4 | 9% |
Student > Master | 4 | 9% |
Student > Doctoral Student | 2 | 4% |
Other | 6 | 13% |
Unknown | 8 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 35% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
Environmental Science | 2 | 4% |
Medicine and Dentistry | 2 | 4% |
Mathematics | 1 | 2% |
Other | 7 | 15% |
Unknown | 11 | 24% |