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Impact of inappropriate antifungal therapy according to current susceptibility breakpoints on Candida bloodstream infection mortality, a retrospective analysis

Overview of attention for article published in BMC Infectious Diseases, December 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

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1 news outlet
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3 X users

Citations

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15 Dimensions

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44 Mendeley
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Title
Impact of inappropriate antifungal therapy according to current susceptibility breakpoints on Candida bloodstream infection mortality, a retrospective analysis
Published in
BMC Infectious Diseases, December 2017
DOI 10.1186/s12879-017-2846-2
Pubmed ID
Authors

María Fernanda González-Lara, Pedro Torres-González, Patricia Cornejo-Juárez, Consuelo Velázquez-Acosta, Areli Martinez-Gamboa, Andrea Rangel-Cordero, Miriam Bobadilla-del-Valle, Luis Ostrosky-Zeichner, Alfredo Ponce-de-León, José Sifuentes-Osornio

Abstract

The mortality of Candida Bloodstream Infection (CBSI) remains high. Antifungal susceptibility breakpoints were recently updated for Candida species, the impact remains unknown. In this study we evaluated the impact of inappropriate antifungal treatment according to recent breakpoints on 30-day mortality of CBSI. From June 2008 to July 2014, data on CBSI episodes from two tertiary-care centers, treated > 72 h were analyzed. Antifungal therapy and 30-day mortality were registered. Inappropriate antifungal treatment according to current Clinical & Laboratory Standards Institute (CLSI) breakpoints was adjusted with 30-day mortality-related co-variates. One hundred forty-nine episodes of CBSI were analyzed. The most frequent species were: C. albicans (40%), C. tropicalis (23%) and C. glabrata complex (20%). According to the 2012 CLSI, 10.7% received inappropriate treatment. The 30-day mortality was 38%; severe sepsis [Odds ratio (OR) 3.4; 95% CI 1.3-8.4], cirrhosis (OR 36; 95% CI 12.2-605), early central venous catheter removal (OR 0.23; 95% CI 0.08-0.66) and previous antifungal therapy (OR 0.15; 95%CI 0.03-0.62), were associated with 30-day mortality by multivariate analysis. Inappropriate antifungal treatment was not (OR 0.19; 95% CI 0.03-1.2). Appropriate antifungal therapy according to CLSI 2012 did not have an impact on mortality. Mortality of CBSI remains high due to disease severity and comorbidities; early antifungal therapy and catheter removal may reduce it.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 25%
Student > Bachelor 6 14%
Student > Postgraduate 4 9%
Researcher 3 7%
Other 2 5%
Other 3 7%
Unknown 15 34%
Readers by discipline Count As %
Medicine and Dentistry 8 18%
Pharmacology, Toxicology and Pharmaceutical Science 7 16%
Biochemistry, Genetics and Molecular Biology 3 7%
Chemistry 3 7%
Agricultural and Biological Sciences 3 7%
Other 4 9%
Unknown 16 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2022.
All research outputs
#3,061,270
of 24,954,788 outputs
Outputs from BMC Infectious Diseases
#990
of 8,392 outputs
Outputs of similar age
#64,690
of 451,911 outputs
Outputs of similar age from BMC Infectious Diseases
#20
of 157 outputs
Altmetric has tracked 24,954,788 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,392 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,911 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 157 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.