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Plant-based solutions for veterinary immunotherapeutics and prophylactics

Overview of attention for article published in Veterinary Research, December 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

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4 X users
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2 Facebook pages

Citations

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41 Dimensions

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178 Mendeley
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Title
Plant-based solutions for veterinary immunotherapeutics and prophylactics
Published in
Veterinary Research, December 2014
DOI 10.1186/s13567-014-0117-4
Pubmed ID
Authors

Igor Kolotilin, Ed Topp, Eric Cox, Bert Devriendt, Udo Conrad, Jussi Joensuu, Eva Stöger, Heribert Warzecha, Tim McAllister, Andrew Potter, Michael D McLean, J Christopher Hall, Rima Menassa

Abstract

An alarming increase in emergence of antibiotic resistance among pathogens worldwide has become a serious threat to our ability to treat infectious diseases according to the World Health Organization. Extensive use of antibiotics by livestock producers promotes the spread of new resistant strains, some of zoonotic concern, which increases food-borne illness in humans and causes significant economic burden on healthcare systems. Furthermore, consumer preferences for meat/poultry/fish produced without the use of antibiotics shape today's market demand. So, it is viewed as inevitable by the One Health Initiative that humans need to reduce the use of antibiotics and turn to alternative, improved means to control disease: vaccination and prophylactics. Besides the intense research focused on novel therapeutic molecules, both these strategies rely heavily on the availability of cost-effective, efficient and scalable production platforms which will allow large-volume manufacturing for vaccines, antibodies and other biopharmaceuticals. Within this context, plant-based platforms for production of recombinant therapeutic proteins offer significant advantages over conventional expression systems, including lack of animal pathogens, low production costs, fast turnaround and response times and rapid, nearly-unlimited scalability. Also, because dried leaves and seeds can be stored at room temperature for lengthy periods without loss of recombinant proteins, plant expression systems have the potential to offer lucrative benefits from the development of edible vaccines and prophylactics, as these would not require "cold chain" storage and transportation, and could be administered in mass volumes with minimal processing. Several biotechnology companies currently have developed and adopted plant-based platforms for commercial production of recombinant protein therapeutics. In this manuscript, we outline the challenges in the process of livestock immunization as well as the current plant biotechnology developments aimed to address these challenges.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Slovakia 1 <1%
Brazil 1 <1%
Japan 1 <1%
Argentina 1 <1%
Unknown 172 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 37 21%
Student > Master 21 12%
Student > Ph. D. Student 19 11%
Other 15 8%
Student > Bachelor 15 8%
Other 24 13%
Unknown 47 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 53 30%
Biochemistry, Genetics and Molecular Biology 16 9%
Social Sciences 10 6%
Medicine and Dentistry 9 5%
Veterinary Science and Veterinary Medicine 7 4%
Other 34 19%
Unknown 49 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2015.
All research outputs
#7,713,861
of 25,373,627 outputs
Outputs from Veterinary Research
#350
of 1,337 outputs
Outputs of similar age
#96,446
of 359,100 outputs
Outputs of similar age from Veterinary Research
#2
of 18 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,337 research outputs from this source. They receive a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,100 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.