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Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors

Overview of attention for article published in Molecular Pain, January 2015
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Title
Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors
Published in
Molecular Pain, January 2015
DOI 10.1186/1744-8069-11-1
Pubmed ID
Authors

Manouela V Valtcheva, Steve Davidson, Chengshui Zhao, Michael Leitges, Robert W Gereau

Abstract

Itch-producing compounds stimulate receptors expressed on small diameter fibers that innervate the skin. Many of the currently known pruritogen receptors are Gq Protein-Coupled Receptors (GqPCR), which activate Protein Kinase C (PKC). Specific isoforms of PKC have been previously shown to perform selective functions; however, the roles of PKC isoforms in regulating itch remain unclear. In this study, we investigated the novel PKC isoform PKCδ as an intracellular modulator of itch signaling in response to histamine and the non-histaminergic pruritogens chloroquine and β-alanine.

X Demographics

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 24%
Researcher 10 22%
Student > Doctoral Student 6 13%
Student > Bachelor 4 9%
Student > Master 4 9%
Other 4 9%
Unknown 6 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 29%
Neuroscience 9 20%
Biochemistry, Genetics and Molecular Biology 7 16%
Medicine and Dentistry 4 9%
Veterinary Science and Veterinary Medicine 2 4%
Other 6 13%
Unknown 4 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2015.
All research outputs
#16,720,137
of 25,368,786 outputs
Outputs from Molecular Pain
#331
of 669 outputs
Outputs of similar age
#209,721
of 358,883 outputs
Outputs of similar age from Molecular Pain
#8
of 11 outputs
Altmetric has tracked 25,368,786 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 358,883 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.