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Protein Kinase Cδ Mediates Histamine-Evoked Itch and Responses in Pruriceptors

Overview of attention for article published in Molecular Pain, January 2015
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  • Average Attention Score compared to outputs of the same age

Mentioned by

twitter
3 tweeters

Citations

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19 Dimensions

Readers on

mendeley
45 Mendeley
Summary Twitter Dimensions citations
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Title
Protein Kinase Cδ Mediates Histamine-Evoked Itch and Responses in Pruriceptors
Published in
Molecular Pain, January 2015
DOI 10.1186/1744-8069-11-1
Pubmed ID
25558916
Authors

Manouela V Valtcheva, Steve Davidson, Chengshui Zhao, Michael Leitges, Robert W Gereau

Abstract

Itch-producing compounds stimulate receptors expressed on small diameter fibers that innervate the skin. Many of the currently known pruritogen receptors are Gq Protein-Coupled Receptors (GqPCR), which activate Protein Kinase C (PKC). Specific isoforms of PKC have been previously shown to perform selective functions; however, the roles of PKC isoforms in regulating itch remain unclear. In this study, we investigated the novel PKC isoform PKCδ as an intracellular modulator of itch signaling in response to histamine and the non-histaminergic pruritogens chloroquine and β-alanine.

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Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 24%
Researcher 10 22%
Student > Doctoral Student 6 13%
Student > Bachelor 4 9%
Student > Master 4 9%
Other 4 9%
Unknown 6 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 29%
Neuroscience 9 20%
Biochemistry, Genetics and Molecular Biology 7 16%
Medicine and Dentistry 4 9%
Veterinary Science and Veterinary Medicine 2 4%
Other 6 13%
Unknown 4 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2015.
All research outputs
#14,793,491
of 22,776,824 outputs
Outputs from Molecular Pain
#294
of 620 outputs
Outputs of similar age
#197,822
of 352,932 outputs
Outputs of similar age from Molecular Pain
#5
of 5 outputs
Altmetric has tracked 22,776,824 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 620 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,932 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.

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