Title |
Two biochemically distinct lipophosphoglycans from Leishmania braziliensis and Leishmania infantum trigger different innate immune responses in murine macrophages
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Published in |
Parasites & Vectors, March 2013
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DOI | 10.1186/1756-3305-6-54 |
Pubmed ID | |
Authors |
Izabela Coimbra Ibraim, Rafael Ramiro de Assis, Natália Lima Pessoa, Marco Antônio Campos, Maria Norma Melo, Salvatore Joseph Turco, Rodrigo Pedro Soares |
Abstract |
The dominant, cell surface lipophosphoglycan (LPG) of Leishmania is a multifunctional molecule involved in the interaction with vertebrate and invertebrate hosts. Although the role of LPG on infection has been extensively studied, it is not known if LPG interspecies variations contribute to the different immunopathologies of leishmaniases. To investigate the issue of interspecies polymorphisms, two Leishmania species from the New World that express structural variations of side chains of LPG repeat units were examined. In this context, the procyclic form of L. braziliensis LPG (strain M2903), is devoid of side chains, while the L. infantum LPG (strain BH46) has up to three glucoses residues in the repeat units. |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Brazil | 3 | 3% |
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Unknown | 114 | 97% |
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Researcher | 13 | 11% |
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Veterinary Science and Veterinary Medicine | 5 | 4% |
Other | 12 | 10% |
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