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To Mia or not to Mia: stepwise evolution of the mitochondrial intermembrane space disulfide relay

Overview of attention for article published in BMC Biology, December 2017
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Title
To Mia or not to Mia: stepwise evolution of the mitochondrial intermembrane space disulfide relay
Published in
BMC Biology, December 2017
DOI 10.1186/s12915-017-0468-1
Pubmed ID
Authors

Chris Carrie, Jürgen Soll

Abstract

The disulfide relay system found in the intermembrane space (IMS) of mitochondria is an essential pathway for the import and oxidative folding of IMS proteins. Erv1, an essential member of this pathway, has been previously found to be ubiquitously present in mitochondria-containing eukaryotes. However, the other essential protein, Mia40, was found to be absent or not required in some organisms, raising questions about how the disulfide relay functions in these organisms. A recent study published in BMC Biology demonstrates for the first time that some Erv1 proteins can function in oxidative folding independently of a Mia40 protein, providing for the first time strong evidence that the IMS disulfide relay evolved in a stepwise manner.See research article: 10.1186/s12915-017-0445-8.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 19%
Researcher 4 19%
Student > Master 3 14%
Student > Ph. D. Student 3 14%
Student > Postgraduate 2 10%
Other 3 14%
Unknown 2 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 43%
Agricultural and Biological Sciences 5 24%
Unspecified 1 5%
Neuroscience 1 5%
Chemistry 1 5%
Other 1 5%
Unknown 3 14%