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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The high-affinity human IgG receptor Fc gamma receptor I (FcγRI) is not associated with vascular leakage of dengue
|
|---|---|
| Published in |
Journal of Negative Results in BioMedicine, January 2015
|
| DOI | 10.1186/s12952-014-0020-6 |
| Pubmed ID | |
| Authors |
Zaiharina Mohamad Zamberi, Zuraihan Zakaria, Abu Thalhah Abdul Aziz, Benedict Sim Lim Heng, Masliza Zaid, Christopher Lee Kwok Chong, Fadzilah Mohd Noor, Sazaly Abu Bakar, Hoh Boon Peng |
| Abstract |
BackgroundDengue is a major public health problem in many tropical and sub-tropical countries. Vascular leakage and shock are identified as the major causes of deaths in patients with severe dengue. Studies have suggested the potential role of Fc gamma receptors I (Fc¿RI) in the pathogenesis of dengue. We hypothesized that the circulating level of Fc¿ receptor I could potentially be used as an indicator in assisting early diagnosis of severe dengue.ResultsA selected cohort of 66 dengue patients including 42 dengue with signs of vascular leakage, and 24 dengue without signs of vascular leakage were identified and were afterwards referred to as `cases¿ and `controls¿ respectively. Thirty seven normal healthy controls were also recruited in this study. The circulating level of Fc¿RI was quantified from the serum using enzyme-link immunosorbent assay (ELISA). The levels of Fc¿RI in both groups of patients with and without vascular leakage were found to be significantly higher than the normal healthy controls (P¿<¿0.001). However, there was no significant difference found between patients with vascular leakage and those without vascular leakage (p¿=¿0.777).ConclusionWe suggest that Fc¿RI is not associated with the vascular leakage in dengue. However, further studies are necessary to delineate the role of Fc¿RI in antibody-dependent enhancement (ADE) mechanism. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 21% |
| Student > Ph. D. Student | 5 | 15% |
| Student > Bachelor | 3 | 9% |
| Other | 2 | 6% |
| Professor | 2 | 6% |
| Other | 6 | 18% |
| Unknown | 8 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 27% |
| Agricultural and Biological Sciences | 5 | 15% |
| Immunology and Microbiology | 5 | 15% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Veterinary Science and Veterinary Medicine | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 10 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2015.
All research outputs
#17,736,409
of 22,776,824 outputs
Outputs from Journal of Negative Results in BioMedicine
#75
of 112 outputs
Outputs of similar age
#241,442
of 352,269 outputs
Outputs of similar age from Journal of Negative Results in BioMedicine
#5
of 8 outputs
Altmetric has tracked 22,776,824 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 112 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,269 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.