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Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo

Overview of attention for article published in Epigenetics & Chromatin, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
1 news outlet
twitter
14 X users

Citations

dimensions_citation
128 Dimensions

Readers on

mendeley
120 Mendeley
citeulike
2 CiteULike
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Title
Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo
Published in
Epigenetics & Chromatin, January 2015
DOI 10.1186/1756-8935-8-1
Pubmed ID
Authors

Julia Arand, Mark Wossidlo, Konstantin Lepikhov, Julian R Peat, Wolf Reik, Jörn Walter

Abstract

DNA methylomes are extensively reprogrammed during mouse pre-implantation and early germ cell development. The main feature of this reprogramming is a genome-wide decrease in 5-methylcytosine (5mC). Standard high-resolution single-stranded bisulfite sequencing techniques do not allow discrimination of the underlying passive (replication-dependent) or active enzymatic mechanisms of 5mC loss. We approached this problem by generating high-resolution deep hairpin bisulfite sequencing (DHBS) maps, allowing us to follow the patterns of symmetric DNA methylation at CpGs dyads on both DNA strands over single replications.

X Demographics

X Demographics

The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Turkey 1 <1%
Switzerland 1 <1%
United Kingdom 1 <1%
Brazil 1 <1%
Unknown 114 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 25%
Researcher 27 23%
Student > Master 18 15%
Student > Doctoral Student 9 8%
Student > Bachelor 8 7%
Other 15 13%
Unknown 13 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 51 43%
Biochemistry, Genetics and Molecular Biology 36 30%
Medicine and Dentistry 6 5%
Neuroscience 2 2%
Nursing and Health Professions 1 <1%
Other 10 8%
Unknown 14 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2015.
All research outputs
#2,067,441
of 25,436,226 outputs
Outputs from Epigenetics & Chromatin
#58
of 614 outputs
Outputs of similar age
#27,523
of 358,890 outputs
Outputs of similar age from Epigenetics & Chromatin
#3
of 13 outputs
Altmetric has tracked 25,436,226 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 614 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 358,890 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.