Title |
CD4+ T cells apoptosis in Plasmodium vivax infection is mediated by activation of both intrinsic and extrinsic pathways
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Published in |
Malaria Journal, January 2015
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DOI | 10.1186/1475-2875-14-5 |
Pubmed ID | |
Authors |
Natália S Hojo-Souza, Dhelio B Pereira, Tiago AO Mendes, Lívia SA Passos, Ana Clara Gazzinelli-Guimarães, Pedro H Gazzinelli-Guimarães, Mauro S Tada, Graziela M Zanini, Daniella C Bartholomeu, Ricardo T Fujiwara, Lilian L Bueno |
Abstract |
Reduction in the number of circulating blood lymphocytes (lymphocytopaenia) has been reported during clinical episodes of malaria and is normalized after treatment with anti-malaria drugs. While this phenomenon is well established in malaria infection, the underlying mechanisms are still not fully elucidated. In the present study, the occurrence of apoptosis and its pathways in CD4+ T cells was investigated in naturally Plasmodium vivax-infected individuals from a Brazilian endemic area (Porto Velho - RO). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Indonesia | 1 | 2% |
Spain | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 44 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 21% |
Student > Master | 7 | 15% |
Student > Ph. D. Student | 7 | 15% |
Researcher | 6 | 13% |
Professor | 3 | 6% |
Other | 4 | 9% |
Unknown | 10 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 21% |
Medicine and Dentistry | 8 | 17% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
Immunology and Microbiology | 5 | 11% |
Computer Science | 1 | 2% |
Other | 3 | 6% |
Unknown | 13 | 28% |