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CD4+ T cells apoptosis in Plasmodium vivax infection is mediated by activation of both intrinsic and extrinsic pathways

Overview of attention for article published in Malaria Journal, January 2015
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Title
CD4+ T cells apoptosis in Plasmodium vivax infection is mediated by activation of both intrinsic and extrinsic pathways
Published in
Malaria Journal, January 2015
DOI 10.1186/1475-2875-14-5
Pubmed ID
Authors

Natália S Hojo-Souza, Dhelio B Pereira, Tiago AO Mendes, Lívia SA Passos, Ana Clara Gazzinelli-Guimarães, Pedro H Gazzinelli-Guimarães, Mauro S Tada, Graziela M Zanini, Daniella C Bartholomeu, Ricardo T Fujiwara, Lilian L Bueno

Abstract

Reduction in the number of circulating blood lymphocytes (lymphocytopaenia) has been reported during clinical episodes of malaria and is normalized after treatment with anti-malaria drugs. While this phenomenon is well established in malaria infection, the underlying mechanisms are still not fully elucidated. In the present study, the occurrence of apoptosis and its pathways in CD4+ T cells was investigated in naturally Plasmodium vivax-infected individuals from a Brazilian endemic area (Porto Velho - RO).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 2%
Spain 1 2%
Brazil 1 2%
Unknown 44 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 21%
Student > Master 7 15%
Student > Ph. D. Student 7 15%
Researcher 6 13%
Professor 3 6%
Other 4 9%
Unknown 10 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 21%
Medicine and Dentistry 8 17%
Biochemistry, Genetics and Molecular Biology 7 15%
Immunology and Microbiology 5 11%
Computer Science 1 2%
Other 3 6%
Unknown 13 28%