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Association analysis of ILVBL gene polymorphisms with aspirin-exacerbated respiratory disease in asthma

Overview of attention for article published in BMC Pulmonary Medicine, December 2017
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Title
Association analysis of ILVBL gene polymorphisms with aspirin-exacerbated respiratory disease in asthma
Published in
BMC Pulmonary Medicine, December 2017
DOI 10.1186/s12890-017-0556-6
Pubmed ID
Authors

Hun Soo Chang, Jong Sook Park, Ho Sung Lee, Jiwon Lyu, Ji-Hye Son, Inseon S. Choi, Hyoung Doo Shin, Choon-Sik Park

Abstract

We previously reported that the ILVBL gene on chromosome 19p13.1 was associated with the risk for aspirin-exacerbated respiratory disease (AERD) and the percent decline of forced expired volume in one second (FEV1) after an oral aspirin challenge test. In this study, we confirmed the association between polymorphisms and haplotypes of the ILVBL gene and the risk for AERD and its phenotype. We recruited 141 AERD and 995 aspirin-tolerant asthmatic (ATA) subjects. All study subjects underwent an oral aspirin challenge (OAC). Nine single nucleotide polymorphisms (SNPs) with minor allele frequencies above 0.05, which were present in the region from 2 kb upstream to 0.5 kb downstream of ILVBL in Asian populations, were selected and genotyped. In an allelic association analysis, seven of nine SNPs were significantly associated with the risk for AERD after correction for multiple comparisons. In a codominant model, the five SNPs making up block2 (rs2240299, rs7507755, rs1468198, rs2074261, and rs13301) showed significant associations with the risk for AERD (corrected P = 0.001-0.004, OR = 0.59-0.64). Rs1468198 was also significantly associated with the percent decline in FEV1 in OAC tests after correction for multiple comparisons in the codominant model (corrected P = 0.033), but the other four SNPs in hapblock2 were not. To the best of our knowledge, this is the first report of an association between SNPs on ILVBL and AERD. SNPs on ILVBL could be promising genetic markers of this condition.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 4 25%
Researcher 2 13%
Student > Bachelor 1 6%
Lecturer 1 6%
Student > Ph. D. Student 1 6%
Other 2 13%
Unknown 5 31%
Readers by discipline Count As %
Medicine and Dentistry 5 31%
Biochemistry, Genetics and Molecular Biology 3 19%
Agricultural and Biological Sciences 2 13%
Immunology and Microbiology 1 6%
Unknown 5 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2017.
All research outputs
#9,838,552
of 12,319,220 outputs
Outputs from BMC Pulmonary Medicine
#665
of 933 outputs
Outputs of similar age
#247,245
of 346,307 outputs
Outputs of similar age from BMC Pulmonary Medicine
#75
of 113 outputs
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So far Altmetric has tracked 933 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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