Title |
Epigenetic mechanisms in virus-induced tumorigenesis
|
---|---|
Published in |
Clinical Epigenetics, March 2011
|
DOI | 10.1007/s13148-011-0026-6 |
Pubmed ID | |
Authors |
Elzbieta Poreba, Justyna Karolina Broniarczyk, Anna Gozdzicka-Jozefiak |
Abstract |
About 15-20% of human cancers worldwide have viral etiology. Emerging data clearly indicate that several human DNA and RNA viruses, such as human papillomavirus, Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, hepatitis B virus, hepatitis C virus, and human T-cell lymphotropic virus, contribute to cancer development. Human tumor-associated viruses have evolved multiple molecular mechanisms to disrupt specific cellular pathways to facilitate aberrant replication. Although oncogenic viruses belong to different families, their strategies in human cancer development show many similarities and involve viral-encoded oncoproteins targeting the key cellular proteins that regulate cell growth. Recent studies show that virus and host interactions also occur at the epigenetic level. In this review, we summarize the published information related to the interactions between viral proteins and epigenetic machinery which lead to alterations in the epigenetic landscape of the cell contributing to carcinogenesis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 4% |
United Kingdom | 1 | 1% |
Portugal | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 76 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 22% |
Researcher | 17 | 21% |
Student > Doctoral Student | 7 | 9% |
Student > Master | 7 | 9% |
Other | 6 | 7% |
Other | 15 | 18% |
Unknown | 12 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 28% |
Biochemistry, Genetics and Molecular Biology | 21 | 26% |
Medicine and Dentistry | 9 | 11% |
Immunology and Microbiology | 6 | 7% |
Linguistics | 2 | 2% |
Other | 4 | 5% |
Unknown | 17 | 21% |