Title |
Cyanidin-3-Glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2
|
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Published in |
Molecular Cancer, October 2010
|
DOI | 10.1186/1476-4598-9-285 |
Pubmed ID | |
Authors |
Mei Xu, Kimberly A Bower, Siying Wang, Jacqueline A Frank, Gang Chen, Min Ding, Shiow Wang, Xianglin Shi, Zunji Ke, Jia Luo |
Abstract |
Ethanol is a tumor promoter. Both epidemiological and experimental studies suggest that ethanol may enhance the metastasis of breast cancer cells. We have previously demonstrated that ethanol increased the migration/invasion of breast cancer cells expressing high levels of ErbB2. Amplification of ErbB2 is found in 20-30% of breast cancer patients and is associated with poor prognosis. We sought to identify agents that can prevent or ameliorate ethanol-induced invasion of breast cancer cells. Cyanidin-3-glucoside (C3G), an anthocyanin present in many vegetables and fruits, is a potent natural antioxidant. Ethanol exposure causes the accumulation of intracellular reactive oxygen species (ROS). This study evaluated the effect of C3G on ethanol-induced breast cancer cell migration/invasion. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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China | 1 | 2% |
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Demographic breakdown
Readers by professional status | Count | As % |
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