Title |
Discovery of DNA methylation markers in cervical cancer using relaxation ranking
|
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Published in |
BMC Medical Genomics, November 2008
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DOI | 10.1186/1755-8794-1-57 |
Pubmed ID | |
Authors |
Maté Ongenaert, G Bea A Wisman, Haukeline H Volders, Alice J Koning, Ate GJ van der Zee, Wim van Criekinge, Ed Schuuring |
Abstract |
To discover cancer specific DNA methylation markers, large-scale screening methods are widely used. The pharmacological unmasking expression microarray approach is an elegant method to enrich for genes that are silenced and re-expressed during functional reversal of DNA methylation upon treatment with demethylation agents. However, such experiments are performed in in vitro (cancer) cell lines, mostly with poor relevance when extrapolating to primary cancers. To overcome this problem, we incorporated data from primary cancer samples in the experimental design. A strategy to combine and rank data from these different data sources is essential to minimize the experimental work in the validation steps. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 20% |
Student > Ph. D. Student | 4 | 20% |
Student > Bachelor | 3 | 15% |
Student > Postgraduate | 3 | 15% |
Researcher | 3 | 15% |
Other | 1 | 5% |
Unknown | 2 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 50% |
Medicine and Dentistry | 4 | 20% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Unspecified | 1 | 5% |
Psychology | 1 | 5% |
Other | 1 | 5% |
Unknown | 2 | 10% |