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The immune modifying effects of amino acids on gut-associated lymphoid tissue

Overview of attention for article published in Journal of Animal Science and Biotechnology, July 2013
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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13 X users

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Title
The immune modifying effects of amino acids on gut-associated lymphoid tissue
Published in
Journal of Animal Science and Biotechnology, July 2013
DOI 10.1186/2049-1891-4-27
Pubmed ID
Authors

Megan R Ruth, Catherine J Field

Abstract

The intestine and the gut-associated lymphoid tissue (GALT) are essential components of whole body immune defense, protecting the body from foreign antigens and pathogens, while allowing tolerance to commensal bacteria and dietary antigens. The requirement for protein to support the immune system is well established. Less is known regarding the immune modifying properties of individual amino acids, particularly on the GALT. Both oral and parenteral feeding studies have established convincing evidence that not only the total protein intake, but the availability of specific dietary amino acids (in particular glutamine, glutamate, and arginine, and perhaps methionine, cysteine and threonine) are essential to optimizing the immune functions of the intestine and the proximal resident immune cells. These amino acids each have unique properties that include, maintaining the integrity, growth and function of the intestine, as well as normalizing inflammatory cytokine secretion and improving T-lymphocyte numbers, specific T cell functions, and the secretion of IgA by lamina propria cells. Our understanding of this area has come from studies that have supplemented single amino acids to a mixed protein diet and measuring the effect on specific immune parameters. Future studies should be designed using amino acid mixtures that target a number of specific functions of GALT in order to optimize immune function in domestic animals and humans during critical periods of development and various disease states.

X Demographics

X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 219 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Denmark 1 <1%
Unknown 217 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 38 17%
Student > Master 34 16%
Researcher 29 13%
Student > Ph. D. Student 27 12%
Other 12 5%
Other 33 15%
Unknown 46 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 60 27%
Medicine and Dentistry 38 17%
Biochemistry, Genetics and Molecular Biology 23 11%
Nursing and Health Professions 10 5%
Immunology and Microbiology 8 4%
Other 22 10%
Unknown 58 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2023.
All research outputs
#3,683,529
of 25,374,647 outputs
Outputs from Journal of Animal Science and Biotechnology
#55
of 903 outputs
Outputs of similar age
#30,762
of 210,110 outputs
Outputs of similar age from Journal of Animal Science and Biotechnology
#2
of 6 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 903 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,110 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.