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Analysis of late toxicity in nasopharyngeal carcinoma patients treated with intensity modulated radiation therapy

Overview of attention for article published in Radiation Oncology, January 2015
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Title
Analysis of late toxicity in nasopharyngeal carcinoma patients treated with intensity modulated radiation therapy
Published in
Radiation Oncology, January 2015
DOI 10.1186/s13014-014-0326-z
Pubmed ID
Authors

YingJie Zheng, Fei Han, WeiWei Xiao, YanQun Xiang, LiXia Lu, XiaoWu Deng, NianJi Cui, Chong Zhao

Abstract

PurposeTo observe the late toxicities in nasopharyngeal carcinoma (NPC) patients who achieved long-term survival after intensity modulated radiation therapy (IMRT).Methods208 untreated NPC patients who received IMRT and survived more than five years with locoregional disease control and no metastasis were evaluated in this study. The prescription dose to the gross target volume of nasopharynx (GTVnx), positive neck lymph nodes (GTVnd), clinical target volume 1 (CTV1) and 2 (CTV2) was 68Gy/30f, 60-66Gy/30f, 60 Gy/30f and 54Gy/30f, respectively. The nasopharynx and upper neck targets were irradiated using IMRT, and the lower neck and supraclavicular fossae targets were irradiated using the half-beam technique with conventional irradiation. The late toxicities were evaluated according to the LENT/SOMA criteria of 1995.ResultsThe median follow-up time was 78 months (60¿96 months). The occurrence rates of cervical subcutaneous fibrosis, hearing loss, skin dystrophy, xerostomia, trismus, temporal lobe injury, cranial nerve damage, cataract, and brain stem injury induced by radiotherapy were 89.9%, 67.8%, 47.6%, 40.9%, 7.21%, 4.33%, 2.88%, 1.44%, and 0.48%, respectively. No spinal cord injury and mandible damage were found. Grade 3¿4 late injuries were observed as follows: 1(0.48%) skin dystrophy, 4(1.92%) cervical subcutaneous fibrosis, 2(0.96%) hearing loss, 2 (0.96%) cranial nerve palsy, and 1(0.48%) temporal lobe necrosis. No grade 3¿4 late injuries occurred in parotid, temporomandibular joints and eyes. Xerostomia decreased gradually over time and then showed only slight changes after 4 years. The change in the incisor distance stabilised by 1 year after RT, however, the incidence of hearing loss, skin dystrophy, subcutaneous fibrosis and nervous system injuries increased over time after RT.ConclusionThe late injuries in most NPC patients who had long-term survivals after IMRT are alleviated. Within the 5 years of follow-up, we found xerostomia decreased gradually; The change in the incisor distance stabilised by 1 year after RT; while hearing loss, nervous system injuries increased over time after RT.

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The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 83 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 16%
Student > Bachelor 10 12%
Student > Ph. D. Student 9 11%
Student > Doctoral Student 7 8%
Professor > Associate Professor 7 8%
Other 20 24%
Unknown 17 20%
Readers by discipline Count As %
Medicine and Dentistry 40 48%
Nursing and Health Professions 5 6%
Physics and Astronomy 3 4%
Biochemistry, Genetics and Molecular Biology 2 2%
Psychology 1 1%
Other 6 7%
Unknown 26 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2016.
All research outputs
#18,389,490
of 22,778,347 outputs
Outputs from Radiation Oncology
#1,410
of 2,052 outputs
Outputs of similar age
#256,323
of 353,085 outputs
Outputs of similar age from Radiation Oncology
#65
of 87 outputs
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We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.