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Mendeley readers
Attention Score in Context
| Title |
Diastolic dysfunction in the diabetic continuum: association with insulin resistance, metabolic syndrome and type 2 diabetes
|
|---|---|
| Published in |
Cardiovascular Diabetology, January 2015
|
| DOI | 10.1186/s12933-014-0168-x |
| Pubmed ID | |
| Authors |
Ricardo Fontes-Carvalho, Ricardo Ladeiras-Lopes, Paulo Bettencourt, Adelino Leite-Moreira, Ana Azevedo |
| Abstract |
BackgroundDiabetes increases the risk of heart failure but the underlying mechanisms leading to diabetic cardiomyopathy are poorly understood. Left ventricle diastolic dysfunction (LVDD) is one of the earliest cardiac changes in these patients. We aimed to evaluate the association between LVDD with insulin resistance, metabolic syndrome (MS) and diabetes, across the diabetic continuum.MethodsWithin a population-based study (EPIPorto), a total of 1063 individuals aged ¿45 years (38% male, 61.2¿±¿9.6 years) were evaluated. Diastolic function was assessed by echocardiography, using tissue Doppler analysis (E¿ velocity and E/E¿ ratio) according to the latest consensus guidelines. Insulin resistance was assessed using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) score.ResultsThe HOMA-IR score correlated to E¿ velocity (¿¿=¿¿0.20;p¿<¿0.0001) and E/E¿ ratio (¿¿=¿0.20; p¿<¿0.0001). There was a progressive worsening in E¿ velocity (p for trend¿<¿0.001) and in E/E¿ ratio across HOMA-IR quartiles (p for trend <0.001). Individuals in the highest HOMA-IR quartile were more likely to have LVDD, even after adjustment for age, sex, blood pressure and body mass index (adjusted OR: 1.82; 95%CI: 1.09-3.03). From individuals with no MS, to patients with MS and no diabetes, to patients with diabetes, there was a progressive decrease in E¿ velocity (11.2¿±¿3.3 vs 9.7¿±¿3.1 vs 9.2¿±¿2.8 cm/s; p¿<¿0.0001), higher E/E¿ (6.9¿±¿2.3 vs 7.8¿±¿2.7 vs 9.0¿±¿3.6; p¿<¿0.0001) and more diastolic dysfunction (adjusted OR: 1.62; 95%CI: 1.12-2.36 and 1.78; 95%CI: 1.09-2.91, respectively).ConclusionsHOMA-IR score and metabolic syndrome were independently associated with LVDD. Changes in diastolic function are already present before the onset of diabetes, being mainly associated with the state of insulin resistance. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Comoros | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 1% |
| Unknown | 97 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 14 | 14% |
| Student > Ph. D. Student | 11 | 11% |
| Student > Master | 11 | 11% |
| Researcher | 10 | 10% |
| Student > Doctoral Student | 6 | 6% |
| Other | 23 | 23% |
| Unknown | 23 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 49% |
| Biochemistry, Genetics and Molecular Biology | 5 | 5% |
| Nursing and Health Professions | 4 | 4% |
| Agricultural and Biological Sciences | 4 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 5 | 5% |
| Unknown | 30 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2015.
All research outputs
#15,170,530
of 25,374,917 outputs
Outputs from Cardiovascular Diabetology
#838
of 1,653 outputs
Outputs of similar age
#186,626
of 360,428 outputs
Outputs of similar age from Cardiovascular Diabetology
#7
of 15 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,653 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,428 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.