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Constitutive heterochromatin formation and transcription in mammals

Overview of attention for article published in Epigenetics & Chromatin, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

twitter
15 tweeters
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
348 Dimensions

Readers on

mendeley
689 Mendeley
citeulike
1 CiteULike
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Title
Constitutive heterochromatin formation and transcription in mammals
Published in
Epigenetics & Chromatin, January 2015
DOI 10.1186/1756-8935-8-3
Pubmed ID
Authors

Nehmé Saksouk, Elisabeth Simboeck, Jérôme Déjardin

Abstract

Constitutive heterochromatin, mainly formed at the gene-poor regions of pericentromeres, is believed to ensure a condensed and transcriptionally inert chromatin conformation. Pericentromeres consist of repetitive tandem satellite repeats and are crucial chromosomal elements that are responsible for accurate chromosome segregation in mitosis. The repeat sequences are not conserved and can greatly vary between different organisms, suggesting that pericentromeric functions might be controlled epigenetically. In this review, we will discuss how constitutive heterochromatin is formed and maintained at pericentromeres in order to ensure their integrity. We will describe the biogenesis and the function of main epigenetic pathways that are involved and how they are interconnected. Interestingly, recent findings suggest that alternative pathways could substitute for well-established pathways when disrupted, suggesting that constitutive heterochromatin harbors much more plasticity than previously assumed. In addition, despite of the heterochromatic nature of pericentromeres, there is increasing evidence for active and regulated transcription at these loci, in a multitude of organisms and under various biological contexts. Thus, in the second part of this review, we will address this relatively new aspect and discuss putative functions of pericentromeric expression.

Twitter Demographics

The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 689 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 6 <1%
Spain 3 <1%
Germany 2 <1%
Czechia 2 <1%
France 1 <1%
Israel 1 <1%
Denmark 1 <1%
Portugal 1 <1%
Korea, Republic of 1 <1%
Other 3 <1%
Unknown 668 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 207 30%
Student > Bachelor 97 14%
Student > Master 93 13%
Researcher 86 12%
Student > Doctoral Student 41 6%
Other 65 9%
Unknown 100 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 265 38%
Agricultural and Biological Sciences 235 34%
Medicine and Dentistry 25 4%
Chemistry 11 2%
Computer Science 10 1%
Other 35 5%
Unknown 108 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2020.
All research outputs
#2,553,668
of 19,529,814 outputs
Outputs from Epigenetics & Chromatin
#100
of 521 outputs
Outputs of similar age
#51,316
of 377,897 outputs
Outputs of similar age from Epigenetics & Chromatin
#6
of 36 outputs
Altmetric has tracked 19,529,814 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 521 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 377,897 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.