Title |
Systems healthcare: a holistic paradigm for tomorrow
|
---|---|
Published in |
BMC Systems Biology, December 2017
|
DOI | 10.1186/s12918-017-0521-2 |
Pubmed ID | |
Authors |
Massimo S. Fiandaca, Mark Mapstone, Elenora Connors, Mireille Jacobson, Edwin S. Monuki, Shaista Malik, Fabio Macciardi, Howard J. Federoff |
Abstract |
Systems healthcare is a holistic approach to health premised on systems biology and medicine. The approach integrates data from molecules, cells, organs, the individual, families, communities, and the natural and man-made environment. Both extrinsic and intrinsic influences constantly challenge the biological networks associated with wellness. Such influences may dysregulate networks and allow pathobiology to evolve, resulting in early clinical presentation that requires astute assessment and timely intervention for successful mitigation. Herein, we describe the components of relevant biological systems and the nature of progression from at-risk to manifest disease. We illustrate the systems approach by examining two relevant clinical examples: Alzheimer's and cardiovascular diseases. The implications of systems healthcare management are examined through the lens of economics, ethics, policy and the law. Finally, we propose the need to develop new educational paradigms to enhance the training of the health professional in an era of systems medicine. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 115 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 14% |
Student > Master | 16 | 14% |
Student > Ph. D. Student | 11 | 10% |
Student > Bachelor | 11 | 10% |
Student > Doctoral Student | 7 | 6% |
Other | 16 | 14% |
Unknown | 38 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 14% |
Nursing and Health Professions | 8 | 7% |
Agricultural and Biological Sciences | 8 | 7% |
Psychology | 7 | 6% |
Computer Science | 7 | 6% |
Other | 28 | 24% |
Unknown | 41 | 36% |