Title |
Anti-malarial activity of indole alkaloids isolated from Aspidosperma olivaceum
|
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Published in |
Malaria Journal, April 2014
|
DOI | 10.1186/1475-2875-13-142 |
Pubmed ID | |
Authors |
Talita PC Chierrito, Anna CC Aguiar, Isabel M de Andrade, Isabela P Ceravolo, Regina AC Gonçalves, Arildo JB de Oliveira, Antoniana U Krettli |
Abstract |
Several species of Aspidosperma (Apocynaceae) are used as treatments for human diseases in the tropics. Aspidosperma olivaceum, which is used to treat fevers in some regions of Brazil, contains the monoterpenoid indole alkaloids (MIAs) aspidoscarpine, uleine, apparicine, and N-methyl-tetrahydrolivacine. Using bio-guided fractionation and cytotoxicity testing in a human hepatoma cell line, several plant fractions and compounds purified from the bark and leaves of the plant were characterized for specific therapeutic activity (and selectivity index, SI) in vitro against the blood forms of Plasmodium falciparum. |
X Demographics
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United Kingdom | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
South Africa | 1 | 1% |
Unknown | 97 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 19 | 19% |
Researcher | 11 | 11% |
Student > Master | 10 | 10% |
Student > Doctoral Student | 8 | 8% |
Student > Bachelor | 8 | 8% |
Other | 18 | 18% |
Unknown | 25 | 25% |
Readers by discipline | Count | As % |
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Chemistry | 22 | 22% |
Agricultural and Biological Sciences | 14 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 13% |
Medicine and Dentistry | 9 | 9% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Other | 13 | 13% |
Unknown | 24 | 24% |