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Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: results of a randomized crossover study and in vitro experiments

Overview of attention for article published in Journal of Translational Medicine, January 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

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3 news outlets
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3 X users

Citations

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29 Dimensions

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119 Mendeley
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Title
Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: results of a randomized crossover study and in vitro experiments
Published in
Journal of Translational Medicine, January 2015
DOI 10.1186/s12967-014-0360-5
Pubmed ID
Authors

Cindy E McCrea, Sheila G West, Penny M Kris-Etherton, Joshua D Lambert, Trent L Gaugler, Danette L Teeter, Katherine A Sauder, Yeyi Gu, Shannon L Glisan, Ann C Skulas-Ray

Abstract

BackgroundData suggest that culinary spices are a potent, low-calorie modality for improving physiological responses to high fat meals. In a pilot study (N¿=¿6 healthy adults), we showed that a meal containing a high antioxidant spice blend attenuated postprandial lipemia by 30% compared to a low spice meal. Our goal was to confirm this effect in a larger sample and to consider the influence of acute psychological stress on fat metabolism. Further, we used in vitro methods to evaluate the inhibitory effect of spices on digestive enzymes.MethodsIn a 2 x 2, randomized, 4-period crossover design, we compared the effects of 14.5 g spices (black pepper, cinnamon, cloves, garlic, ginger, oregano, paprika, rosemary, and turmeric) vs. placebo incorporated into a high fat meal (1000 kcal, 45 g fat), followed by psychological stress (Trier Social Stress Test) vs. rest on postprandial metabolism in 20 healthy but overweight adults. Blood was sampled at baseline and at 105, 140, 180, and 210 minutes for analysis of triglycerides, glucose, and insulin. Additional in vitro analyses examined the effect of the spice blend and constituent spices on the activity of pancreatic lipase (PL) and secreted phospholipase A2 (PLA2). Mixed models were used to model the effects of spices and stress (SAS v9.3).ResultsSerum triglycerides, glucose and insulin were elevated following the meal (p¿<¿0.01). Spices reduced post-meal triglycerides by 31% when the meal was followed by the rest condition (p¿=¿0.048), but this effect was not present during stress. There was no effect of the spice blend on glucose or insulin; however, acute stress significantly increased both of these measures (p¿<¿0.01; mean increase of 47% and 19%, respectively). The spice blend and several of the individual spices dose-dependently inhibited PL and PLA2 activity in vitro.ConclusionsInclusion of spices may attenuate postprandial lipemia via inhibition of PL and PLA2. However, the impact of psychological stress negates any influence of the spice blend on triglycerides, and further, increases blood glucose and insulin.Trial registrationClinicalTrials.gov as NCT00954902).

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Brazil 1 <1%
Unknown 117 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 13%
Student > Bachelor 14 12%
Student > Ph. D. Student 12 10%
Student > Doctoral Student 11 9%
Student > Master 11 9%
Other 13 11%
Unknown 43 36%
Readers by discipline Count As %
Medicine and Dentistry 14 12%
Nursing and Health Professions 10 8%
Biochemistry, Genetics and Molecular Biology 8 7%
Psychology 8 7%
Agricultural and Biological Sciences 7 6%
Other 24 20%
Unknown 48 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2024.
All research outputs
#1,459,100
of 25,255,356 outputs
Outputs from Journal of Translational Medicine
#272
of 4,600 outputs
Outputs of similar age
#19,853
of 364,356 outputs
Outputs of similar age from Journal of Translational Medicine
#8
of 126 outputs
Altmetric has tracked 25,255,356 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,600 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 364,356 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.