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Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma

Overview of attention for article published in Journal of Translational Medicine, January 2015
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  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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3 X users

Citations

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53 Dimensions

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66 Mendeley
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Title
Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma
Published in
Journal of Translational Medicine, January 2015
DOI 10.1186/s12967-014-0376-x
Pubmed ID
Authors

Ines Chevolet, Reinhart Speeckaert, Max Schreuer, Bart Neyns, Olga Krysko, Claus Bachert, Mireille Van Gele, Nanja van Geel, Lieve Brochez

Abstract

BackgroundImmune markers in the peripheral blood of melanoma patients could provide prognostic information. However, there is currently no consensus on which circulating cell types have more clinical impact. We therefore evaluated myeloid-derived suppressor cells (MDSC), dendritic cells (DC), cytotoxic T-cells and regulatory T-cells (Treg) in a series of blood samples of melanoma patients in different stages of disease.MethodsFlow cytometry was performed on peripheral blood mononuclear cells of 69 stage I to IV melanoma patients with a median follow-up of 39 months after diagnosis to measure the percentage of monocytic MDSCs (mMDSCs), polymorphonuclear MDSCs (pmnMDSCs), myeloid DCs (mDCs), plasmacytoid DCs (pDCs), cytotoxic T-cells and Tregs. We also assessed the expression of PD-L1 and CTLA-4 in cytotoxic T-cells and Tregs respectively. The impact of cell frequencies on prognosis was tested with multivariate Cox regression modelling.ResultsCirculating pDC levels were decreased in patients with advanced (P¿=¿0.001) or active (P¿=¿0.002) disease. Low pDC levels conferred an independent negative impact on overall (P¿=¿0.025) and progression-free survival (P¿=¿0.036). Even before relapse, a decrease in pDC levels was observed (P¿=¿0.002, correlation coefficient 0.898). High levels of circulating MDSCs (>4.13%) have an independent negative prognostic impact on OS (P¿=¿0.012). MDSC levels were associated with decreased CD3+ (P¿<¿0.001) and CD3¿+¿CD8+ (P¿=¿0.017) T-cell levels. Conversely, patients with high MDSC levels had more PD-L1+ T-cells (P¿=¿0.033) and more CTLA-4 expression by Tregs (P¿=¿0.003). pDCs and MDSCs were inversely correlated (P¿=¿0.004). The impact of pDC levels on prognosis and prediction of the presence of systemic disease was stronger than that of MDSC levels.ConclusionWe demonstrated that circulating pDC and MDSC levels are inversely correlated but have an independent prognostic value in melanoma patients. These cell types represent a single immunologic system and should be evaluated together. Both are key players in the immunological climate in melanoma patients, as they are correlated with circulating cytotoxic and regulatory T-cells. Circulating pDC and MDSC levels should be considered in future immunoprofiling efforts as they could impact disease management.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 2%
Unknown 65 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 14%
Other 6 9%
Student > Bachelor 6 9%
Student > Doctoral Student 6 9%
Student > Ph. D. Student 6 9%
Other 18 27%
Unknown 15 23%
Readers by discipline Count As %
Medicine and Dentistry 17 26%
Immunology and Microbiology 9 14%
Biochemistry, Genetics and Molecular Biology 7 11%
Agricultural and Biological Sciences 5 8%
Unspecified 4 6%
Other 5 8%
Unknown 19 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
#12,910,051
of 22,778,347 outputs
Outputs from Journal of Translational Medicine
#1,475
of 3,987 outputs
Outputs of similar age
#164,349
of 352,360 outputs
Outputs of similar age from Journal of Translational Medicine
#47
of 127 outputs
Altmetric has tracked 22,778,347 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,987 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,360 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.