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Attention Score in Context
| Title |
Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil
|
|---|---|
| Published in |
BMC Infectious Diseases, January 2015
|
| DOI | 10.1186/s12879-015-0751-0 |
| Pubmed ID | |
| Authors |
Fabiana Covolo de Souza-Santana, Elaine Valim Camarinha Marcos, Maria Esther Salles Nogueira, Somei Ura, Jane Tomimori |
| Abstract |
BackgroundEvidence suggests that human leukocyte antigen (HLA) alleles influence the host immune response against Mycobacterium leprae. However, the association between HLA alleles and borderline (B) leprosy has not been studied. The aim of this study was to determine whether HLA class I and II molecules are associated with susceptibility or resistance to B leprosy including borderline-tuberculoid (BT), borderline-borderline (BB), and borderline-lepromatous (BL).MethodsDNA was obtained by the salting-out technique from the blood samples of 202 patients with B leprosy and 478 control subjects. HLA class I (A*, B*, and C* loci) and class II (DRB1* and DQB1* loci) genotypes were determined by polymerase chain reaction amplification and reverse hybridization with sequence-specific oligonucleotide probes and sequence-specific primers.ResultsThe case-controlled analysis results showed a significant association between B leprosy and HLA-C*05 (5.94% vs. 14.02%; p¿=¿0.002, OR¿=¿0.38, 95%CI¿=¿0.20¿0.73, pc¿=¿0.032) and HLA-DRB1*07 (16.34% vs. 26.77%; p¿=¿0.003, OR¿=¿0.53, 95%CI¿=¿0.3¿0.8, pc¿=¿0.039). A protective association was observed between BL leprosy and HLA-DQB1*02 (18.18% vs. 39.53%; p¿=¿0.005, OR¿=¿0.34, 95%CI¿=¿0.15¿0.75, pc¿=¿0.025). In reactional patients, a significant association was observed between HLA-B*15 (28.72% vs. 12.76%; p¿=¿0.011, OR¿=¿2.75, 95%CI¿=¿1.30¿5.85, pc¿=¿0.352) and predisposition to reversal reaction. Haplotype analysis showed that A*02-B*07-C*07-DRB1*15-DQB1*06 (2.97% vs. 1.04%; p¿=¿0.015) and A*02-B*40-C*03-DRB1*13-DQB1*06 (1.73% vs. 0.10%; p¿=¿0.0011) were associated with susceptibility to the B form. The presence of the HLA-DRB1*02 or HLA-DRB1*03/HLA-DQB1*01 haplotypes in B patients (22.05% vs. 33.0%; p¿=¿0.005) suggested the involvement of these haplotypes in this clinical form of the disease.ConclusionsThe results indicate the involvement of HLA class I and class II molecules in B leprosy and reversal reactions; it also suggest a role for HLA in polarization of the disease in this group of patients. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 8 | 21% |
| Student > Ph. D. Student | 7 | 18% |
| Student > Master | 4 | 10% |
| Student > Bachelor | 4 | 10% |
| Other | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 8 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 28% |
| Agricultural and Biological Sciences | 9 | 23% |
| Medicine and Dentistry | 4 | 10% |
| Nursing and Health Professions | 2 | 5% |
| Immunology and Microbiology | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 9 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2015.
All research outputs
#19,292,491
of 23,881,329 outputs
Outputs from BMC Infectious Diseases
#5,794
of 7,931 outputs
Outputs of similar age
#262,500
of 356,812 outputs
Outputs of similar age from BMC Infectious Diseases
#118
of 175 outputs
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We're also able to compare this research output to 175 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.