Title |
Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection
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Published in |
BMC Systems Biology, December 2014
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DOI | 10.1186/1752-0509-8-s5-s6 |
Pubmed ID | |
Authors |
Che Lin, Chin-Nan Lin, Yu-Chao Wang, Fang-Yu Liu, Yu-Wen Chien, Yung-Jen Chuang, Chung-Yu Lan, Wen-Ping Hsieh, Bor-Sen Chen |
Abstract |
Candida albicans has emerged as an important model organism for the study of infectious disease. Using high-throughput simultaneously quantified time-course transcriptomics, this study constructed host-pathogen interspecies interaction networks between C. albicans and zebrafish during the adhesion, invasion, and damage stages. Given that iron and glucose have been identified as crucial resources required during the infection process between C. albicans and zebrafish, we focused on the construction of the interspecies networks associated with them. Furthermore, a randomization technique was proposed to identify differentially regulated proteins that are statistically eminent for the three infection stages. The behaviors of the highly connected or differentially regulated proteins identified from the resulting networks were further investigated. |
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France | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 10% |
Unknown | 19 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 24% |
Student > Postgraduate | 4 | 19% |
Student > Ph. D. Student | 4 | 19% |
Researcher | 3 | 14% |
Unspecified | 1 | 5% |
Other | 1 | 5% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 5 | 24% |
Medicine and Dentistry | 3 | 14% |
Immunology and Microbiology | 2 | 10% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Unspecified | 1 | 5% |
Other | 4 | 19% |
Unknown | 5 | 24% |